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Review
. 2014 Jun;2(2):60-90.
doi: 10.1002/sm2.28.

An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE)

Stanley E Althof  1 , Chris G McMahon  2 , Marcel D Waldinger  3 , Ege Can Serefoglu  4 , Alan W Shindel  5 , P Ganesan Adaikan  6 , Edgardo Becher  7 , John Dean  8 , Francois Giuliano  9 , Wayne Jg Hellstrom  10 , Annamaria Giraldi  11 , Sidney Glina  12 , Luca Incrocci  13 , Emmanuele Jannini  14 , Marita McCabe  15 , Sharon Parish  16 , David Rowland  17 , R Taylor Segraves  18 , Ira Sharlip  19 , Luiz Otavio Torres  20
Affiliations
Review

An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE)

Stanley E Althof et al. Sex Med. 2014 Jun.

Abstract

Introduction: In 2009, the International Society for Sexual Medicine (ISSM) convened a select panel of experts to develop an evidence-based set of guidelines for patients suffering from lifelong premature ejaculation (PE). That document reviewed definitions, etiology, impact on the patient and partner, assessment, and pharmacological, psychological, and combined treatments. It concluded by recognizing the continually evolving nature of clinical research and recommended a subsequent guideline review and revision every fourth year. Consistent with that recommendation, the ISSM organized a second multidisciplinary panel of experts in April 2013, which met for 2 days in Bangalore, India. This manuscript updates the previous guidelines and reports on the recommendations of the panel of experts.

Aim: The aim of this study was to develop clearly worded, practical, evidenced-based recommendations for the diagnosis and treatment of PE for family practice clinicians as well as sexual medicine experts.

Method: A comprehensive literature review was performed.

Results: This article contains the report of the second ISSM PE Guidelines Committee. It offers a new unified definition of PE and updates the previous treatment recommendations. Brief assessment procedures are delineated, and validated diagnostic and treatment questionnaires are reviewed. Finally, the best practices treatment recommendations are presented to guide clinicians, both familiar and unfamiliar with PE, in facilitating treatment of their patients.

Conclusion: Development of guidelines is an evolutionary process that continually reviews data and incorporates the best new research. We expect that ongoing research will lead to a more complete understanding of the pathophysiology as well as new efficacious and safe treatments for this sexual dysfunction. We again recommend that these guidelines be reevaluated and updated by the ISSM in 4 years. Althof SE, McMahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, Becher E, Dean J, Giuliano F, Hellstrom WJG, Giraldi A, Glina S, Incrocci L, Jannini E, McCabe M, Parish S, Rowland D, Segraves RT, Sharlip I, and Torres LO. An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE). Sex Med 2014;2:60-90.

Keywords: Definition of PE; Diagnosis of PE; Etiology of PE; Pharmacotherapy of PE; Premature Ejaculation; Prevalence of PE; Psychotherapy of PE.

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Figures

Figure 1
Figure 1
Algorithm for the management of PE (with permission of D. Rowland). ED = erectile dysfunction; PE = premature ejaculation
See this image and copyright information in PMC

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References

    1. Althof S, Abdo C, Dean J, Hackett G, McCabe M, McMahon CG, Rosen RC, Sadovsky R, Waldinger MD, Becher E, Broderick G, Buvat J, Goldstein I, El-Meliegy A, Giuliano F, Hellstrom W, Incrocci L, Jannini EA, Park K, Parish S, Porst H, Rowland D, Segraves R, Sharlip I, Simonelli C, Tan HM. International Society for Sexual Medicine's Guidelines for the diagnosis and treatment of premature ejaculation. J Sex Med. 2010;7:2947–2969. - PubMed
    1. Centre for Evidence Based Medicine. Oxford Centre for Evidence Based Medicine levels of evidence. 2001. Available at: http://www.cebm.net (accessed August 5, 2013)
    1. Jannini E, Eardley I, Sand M, Hackett G. Clinical and basic science research in sexual medicine must rely, in part, on pharmaceutical funding? J Sex Med. 2010;7:2331–2337. - PubMed
    1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th edition, text revision. Washington, DC: American Psychiatric Association; 2000.
    1. Colpi G, Weidner W, Jungwirth A, Pomerol J, Papp G, Hargreave T, Dohle G. EAU guidelines on ejaculatory dysfunction. Eur Urol. 2004;46:555–558. - PubMed