The stimulus selectivity and connectivity of layer six principal cells reveals cortical microcircuits underlying visual processing
- PMID: 25175879
- PMCID: PMC4175007
- DOI: 10.1016/j.neuron.2014.08.001
The stimulus selectivity and connectivity of layer six principal cells reveals cortical microcircuits underlying visual processing
Erratum in
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The Stimulus Selectivity and Connectivity of Layer Six Principal Cells Reveals Cortical Microcircuits Underlying Visual Processing.Neuron. 2014 Oct 1;84(1):238. doi: 10.1016/j.neuron.2014.09.026. Epub 2014 Oct 1. Neuron. 2014. PMID: 28898623 Free PMC article. No abstract available.
Abstract
Sensory computations performed in the neocortex involve layer six (L6) cortico-cortical (CC) and cortico-thalamic (CT) signaling pathways. Developing an understanding of the physiological role of these circuits requires dissection of the functional specificity and connectivity of the underlying individual projection neurons. By combining whole-cell recording from identified L6 principal cells in the mouse primary visual cortex (V1) with modified rabies virus-based input mapping, we have determined the sensory response properties and upstream monosynaptic connectivity of cells mediating the CC or CT pathway. We show that CC-projecting cells encompass a broad spectrum of selectivity to stimulus orientation and are predominantly innervated by deep layer V1 neurons. In contrast, CT-projecting cells are ultrasparse firing, exquisitely tuned to orientation and direction information, and receive long-range input from higher cortical areas. This segregation in function and connectivity indicates that L6 microcircuits route specific contextual and stimulus-related information within and outside the cortical network.
Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
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Comment in
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Visual processing: microcircuits unmasked.Nat Rev Neurosci. 2014 Oct;15(10):632. doi: 10.1038/nrn3834. Nat Rev Neurosci. 2014. PMID: 25234258 No abstract available.
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