Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jan:78:142-53.
doi: 10.1016/j.yjmcc.2014.08.015. Epub 2014 Aug 27.

Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury

Giampaolo Morciano  1 , Carlotta Giorgi  1 , Massimo Bonora  1 , Silvia Punzetti  2 , Rita Pavasini  2 , Mariusz R Wieckowski  3 , Gianluca Campo  2 , Paolo Pinton  4
Affiliations
Review

Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury

Giampaolo Morciano et al. J Mol Cell Cardiol. 2015 Jan.

Abstract

The mitochondrial permeability transition is a key event in cell death. Intense research efforts have been focused on elucidating the molecular components of the mitochondrial permeability transition pore (mPTP) to improve the understanding and treatment of various pathologies, including neurodegenerative disorders, cancer and cardiac diseases. Several molecular factors have been proposed as core components of the mPTP; however, further investigation has indicated that these factors are among a wide range of regulators. Thus, the scientific community lacks a clear model of the mPTP. Here, we review the molecular factors involved in the regulation and formation of the mPTP. Furthermore, we propose that the mitochondrial ATP synthase, specifically its c subunit, is the central core component of the mPTP complex. Moreover, we discuss the involvement of the mPTP in ischemia and reperfusion as well as the results of clinical studies targeting the mPTP to ameliorate ischemia-reperfusion injury. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease".

Keywords: Apoptosis; Cell death; Ischemia reperfusion injury; Mitochondrial permeability transition pore, MPTP; Necrosis; Permeability transition pore, PTP.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

Substances

LinkOut - more resources