Obsessive-compulsive disorder
- PMID: 25150561
- DOI: 10.1016/j.psc.2014.06.004
Obsessive-compulsive disorder
Abstract
This article reviews the clinical features and neurochemical hypotheses of obsessive-compulsive disorder (OCD) with a focus on the serotonin system. In DSM-5, OCD was moved from the anxiety disorders to a new category of Obsessive-Compulsive and Related Disorders. OCD is a common, typically persistent disorder marked by intrusive and disturbing thoughts (obsessions) and repetitive behaviors (compulsions) that the person feels driven to perform. The preferential efficacy of serotonin reuptake inhibitors (SRIs) in OCD led to the so-called serotonin hypothesis. However, direct support for a role of serotonin in the pathophysiology (e.g., biomarkers in pharmacological challenge studies) of OCD remains elusive. A role of the glutamatergic system in OCD has been gaining traction based on imaging data, genomic studies and animal models of aberrant grooming behavior. These findings have spurred interest in testing the efficacy of medications that modulate glutamate function. A role of glutamate is compatible with circuit-based theories of OCD.
Keywords: Compulsions; Cortico-striato-thalamo-cortical (CSTC) circuit; Glutamate; History; Obsessions; Obsessive-compulsive disorder (OCD); Serotonin; Serotonin reuptake inhibitors (SRIs).
Copyright © 2014 Elsevier Inc. All rights reserved.
Similar articles
-
[Current and emerging features of obsessive-compulsive disorder--trends for the revision of DSM-5].Seishin Shinkeigaku Zasshi. 2012;114(9):1023-30. Seishin Shinkeigaku Zasshi. 2012. PMID: 23198591 Review. Japanese.
-
Obsessive-compulsive disorder.J Pharm Pract. 2014 Apr;27(2):116-30. doi: 10.1177/0897190014521996. Epub 2014 Feb 27. J Pharm Pract. 2014. PMID: 24576790 Review.
-
Obsessive-Compulsive Disorder.Continuum (Minneap Minn). 2018 Jun;24(3, BEHAVIORAL NEUROLOGY AND PSYCHIATRY):828-844. doi: 10.1212/CON.0000000000000603. Continuum (Minneap Minn). 2018. PMID: 29851880 Review.
-
[Obsessive-compulsive disorder in children and adolescents].Harefuah. 2008 Apr;147(4):324-9, 374, 373. Harefuah. 2008. PMID: 18686815 Review. Hebrew.
-
A review of animal models of obsessive-compulsive disorder: a focus on developmental, immune, endocrine and behavioral models.Expert Opin Drug Discov. 2016;11(1):27-43. doi: 10.1517/17460441.2016.1103225. Epub 2015 Nov 11. Expert Opin Drug Discov. 2016. PMID: 26558411 Review.
Cited by
-
Comparing the 'When' and the 'Where' of Electrocortical Activity in Patients with Tourette Syndrome, Body-Focused Repetitive Behaviors, and Obsessive Compulsive Disorder.J Clin Med. 2024 Apr 24;13(9):2489. doi: 10.3390/jcm13092489. J Clin Med. 2024. PMID: 38731020 Free PMC article.
-
Identification of key mRNAs and signaling pathways in obsessive compulsive disorder based on weighted gene co-expression network analysis and cytoHubba plugin.Brain Behav. 2024 May;14(5):e3412. doi: 10.1002/brb3.3412. Brain Behav. 2024. PMID: 38664915 Free PMC article.
-
Neuronal correlates of intensification and acceptance of symptoms during exposure therapy in patients with obsessive-compulsive disorder.Front Psychol. 2024 Feb 5;15:1256046. doi: 10.3389/fpsyg.2024.1256046. eCollection 2024. Front Psychol. 2024. PMID: 38375106 Free PMC article.
-
Autistic Traits as Predictors of Increased Obsessive-Compulsive Disorder Severity: The Role of Inflexibility and Communication Impairment.Brain Sci. 2024 Jan 9;14(1):64. doi: 10.3390/brainsci14010064. Brain Sci. 2024. PMID: 38248279 Free PMC article.
-
Association of granulocyte macrophage colony-stimulating factor and interleukin-17 levels with obsessive-compulsive disorder: a case-control study findings.Sci Rep. 2023 Nov 3;13(1):18976. doi: 10.1038/s41598-023-46401-8. Sci Rep. 2023. PMID: 37923827 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical