Novel gene identified in an exome-wide association study of tanning dependence
- PMID: 25041255
- PMCID: PMC4204712
- DOI: 10.1111/exd.12503
Novel gene identified in an exome-wide association study of tanning dependence
Abstract
Growing evidence suggests that some individuals may exhibit symptoms of dependence to ultraviolet light, a known carcinogen, in the context of tanning. Genetic associations with tanning dependence (TD) have not yet been explored. We conducted an exome-wide association study in 79 individuals who exhibited symptoms of TD and 213 individuals with volitional exposure to ultraviolet light, but who were not TD based on three TD scales. A total of 300 000 mostly exomic single nucleotide polymorphisms primarily in coding regions were assessed using an Affymetrix Axiom array. We performed a gene burden test with Bonferroni correction for the number of genes examined (P < 0.05/14 904 = 3.36 × 10(-6) ). One gene, patched domain containing 2 (PTCHD2), yielded a statistically significant P-value of 2.5 × 10(-6) (OR = 0.27) with fewer individuals classified as TD having a minor allele at this locus. These results require replication, but are the first to support a specific genetic association with TD.
Keywords: PTCHD2 gene; genetic association; tanning dependence.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Conflict of interest statement
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References
-
- Kaur M, Liguori A, Lang W, Rapp SR, Fleischer AB, Jr, Feldman SR. Induction of withdrawal-like symptoms in a small randomized, controlled trial of opioid blockade in frequent tanners. Journal of the American Academy of Dermatology. 2006;54:709–711. - PubMed
-
- American Psychiatric Association. Diagnostic criteria from DSM-IV-TR. Washington, D.C.: American Psychiatric Association; 2000.
-
- Mayfield D, McLeod G, Hall P. The CAGE questionnaire: validation of a new alcoholism screening instrument. Am J Psychiatry. 1974;131:1121–1123. - PubMed
-
- Warthan MM, Uchida T, Wagner RF., Jr. UV light tanning as a type of substance-related disorder. Arch Dermatol. 2005;141:963–966. - PubMed
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