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. 2014;81(3):130-8.
doi: 10.1272/jnms.81.130.

The effects of polymyxin B-immobilized fiber hemoperfusion on respiratory impairment in endotoxemic pigs

Hiroyuki Koami  1 , Yuichiro Sakamoto, Taku Miyasho, Takaharu Itami, Jun Tamura, Tomohito Ishizuka, Yoshio Kawamura, Kozo Nakamura, Kenjirou Miyoshi, Kazuto Yamashita
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Free article

The effects of polymyxin B-immobilized fiber hemoperfusion on respiratory impairment in endotoxemic pigs

Hiroyuki Koami et al. J Nippon Med Sch. 2014.
Free article

Abstract

Purpose: This study investigated the effects of direct hemoperfusion with polymyxin B-immobilized fibers (PMX-DHP) on respiratory impairment in endotoxemic pigs.

Materials and methods: Thirteen anesthetized, mechanically ventilated pigs were divided into PMX-DHP (n=7) and control (n=6) groups. All pigs were hemodynamically monitored with the pulse index contour cardiac output (PiCCO) system (Pulsion Medical Systems, Munich, Germany) and infused intravenously with live Escherichia coli (LD50). In the PMX-DHP group, an arteriovenous extracorporeal circuit with a PMX column was applied for 30 to 150 minutes after endotoxin injection. We analyzed the laboratory data, arterial blood gas levels, and PiCCO variables (extravascular lung water [EVLW] and pulmonary vascular permeability index [PVPI]). Furthermore, we performed computed tomography of the chest in all pigs. The data were statistically analyzed with Student's t-test, the chi-square test, and the Mann-Whitney U-test.

Results: With PMX-DHP endotoxemia significantly decreased and blood pressure increased 150 minutes after endotoxin injection. PiCCO revealed more cases of decreased EVLW in the PMX-DHP group. PVPI increased after endotoxin infusion in both groups. Computed tomography showed improvements in the PMX-DHP group. The survival rate was greater in the PMX-DHP group (100%) than in the control group (71%).

Conclusion: PMX-DHP is effective for treating respiratory impairment and contributes to the decreased mortality rate in the endotoxemic pigs.

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