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doi: 10.1016/j.stem.2014.06.015.
Your heart on a chip: iPSC-based modeling of Barth-syndrome-associated cardiomyopathy
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- PMID: 24996164
- DOI: 10.1016/j.stem.2014.06.015
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Your heart on a chip: iPSC-based modeling of Barth-syndrome-associated cardiomyopathy
Cell Stem Cell.
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Abstract
Disease-specific induced pluripotent stem cells (iPSCs) are invaluable tools for studying genetic disorders in a dish. A recent paper by Wang et al. (2014) powerfully combines analysis of human iPSCs with genome editing and tissue engineering, in conjunction with biochemical and physiological assays, to provide insights into Barth-syndrome-associated cardiomyopathy.
Copyright © 2014 Elsevier Inc. All rights reserved.
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Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies.Nat Med. 2014 Jun;20(6):616-23. doi: 10.1038/nm.3545. Epub 2014 May 11. Nat Med. 2014. PMID: 24813252 Free PMC article.
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