Remifentanil versus Fentanyl for Assisted Reproductive Technologies: Effect on Hemodynamic Recovery from Anesthesia and Outcome of ART Cycles
- PMID: 24963364
- PMCID: PMC4059954
Remifentanil versus Fentanyl for Assisted Reproductive Technologies: Effect on Hemodynamic Recovery from Anesthesia and Outcome of ART Cycles
Abstract
Background: We conducted this study to compare the outcome of assisted reproductive technology (ART) procedures and recovery from anesthesia in women who received opioid analgesia with remifentanil versus fentanyl.
Materials and methods: This double-blind, randomized clinical trial was carried out in the Yazd Research and Clinical Center for Infertility, Yazd, Iran. We studied 145 women who were participants in an ART program. During the first phase of the study, all patients underwent induction of anesthesia with thiopental and received analgesia with remifentanil or fentanyl. The primary endpoint was pregnancy rate per transfer. The numbers of oocytes collected, fertilized and cleaved were recorded, as was the number of oocytes transferred and recovery profile. In the second phase of the study, all patients were followed for outcome of ART cycle.
Results: This study suggested that in women undergoing transvaginal ultrasound-guided oocyte retrieval procedures, the likelihood of a successful pregnancy was higher with a remifentanil-based monitored anesthesia care (MAC) technique than with a fentanyl-based MAC technique. The recovery from anesthesia was significantly better in the remifentanil group versus fentanyl group.
Conclusion: The results of this study suggest that remifentanil in clinical practice is superior to fentanyl (
Registration number: IRCT201009283468N3).
Keywords: Analgesia; Assisted Reproductive Technologies; Fentanyl; Remifentanil.
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References
-
- Soussis I, Boyd O, Paraschos T, Duffy S, Bower S, Troughton P, et al. Follicular fluid levels of midazolam, fentanyl, and alfentanil during transvaginal oocyte retrieval. Fertil Steril. 1995;64(5):1003–1007. - PubMed
-
- Endler GC, Stout M, Magyar DM, Hayes MF, Moghissi KS, Sacco AG. Follicular fluid concentrations of thiopental and thiamylal during laparoscopy for oocyte retrieval. Fertil Steril. 1987;48(5):828–833. - PubMed
-
- Achwal M, Abuzeid M, Bovenschen JL, Lawrence K, Jones ML, Verrill H, et al. Remifentanil and fentanyl concentrations in follicular fluid during transvaginal oocyte retrieval. Anesthesiology. 1999;90:A16–A16.
-
- Chetkowski RJ, Nass TE. Isoflurane inhibits early mouse embryo development in vitro. Fertil Steril. 1988;49(1):171–173. - PubMed
-
- Vincent RD Jr, Syrop CH, Van Voorhis BJ, Chestnut DH, Sparks AE, McGrath JM, et al. An evaluation of the effect of anesthetic technique on reproductive success after laparoscopic pronuclear stage transfer.Propofol/nitrous oxide versus isoflurane/nitrous oxide. Anesthesiology. 1995;82(2):352–358. - PubMed
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