Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jan;12(1):77-82.

Propofol or Thiopental sodium in patients undergoing reproductive assisted technologies: Differences in hemodynamic recovery and outcome of oocyte retrieval: A randomized clinical trial

Mohammad Hossein Jarahzadeh  1 , Reza Jouya  2 , Fatemeh Sadat Mousavi  1 , Mohammad Dehghan-Tezerjani  3 , Shekoofa Behdad  3 , Hamid Reza Soltani  4
Affiliations

Propofol or Thiopental sodium in patients undergoing reproductive assisted technologies: Differences in hemodynamic recovery and outcome of oocyte retrieval: A randomized clinical trial

Mohammad Hossein Jarahzadeh et al. Iran J Reprod Med. 2014 Jan.

Abstract

Background: Thiopental sodium and Propofol are two widely-used drugs in the induction of anesthesia in assisted reproductive technology (ART). However, the side effects and outcome of recovery from anesthesia of these drugs on ART have not been identified yet.

Objective: This study aimed at investigating the side effects and hemodynamic effects of using thiopental sodium and propofal as well as effects of these drugs on pregnancy outcome in ART cycles.

Materials and methods: In this double blinded) randomized controlled trial, 90 woman candidate for ART were randomly divided into two groups. 47 patients received Propofol (2.5 mg/kg) and 43 patients received thiopental (5mg/kg) for anesthesia induction. The entry hemodynamic parameters of the patients were documented. During the anesthesia process, hemodynamic parameters were checked at five-minute intervals.

Results: The results of the study showed a statistically significant difference between two groups in terms of their response to verbal stimulation (p<0.001), the normalization time of the rate and quality of breathing (p<0.001), nausea (p<0.001), and vomiting (p<0.001). Also, in comparison with the other group, all these parameters were better in Propofol group. There was found no significant difference between two groups in terms of other variables.

Conclusion: Based on the findings of the study, Propofol has fewer known side effects. Vomiting and nausea as two known side effect of anesthesia are significantly lower in patients receiving Propofol than patients who received thiopental.

Registration id in irct: IRCT201303135393N2 This article extracted from M.D. thesis. (Reza Jouya).

Keywords: Assisted reproductive technology.; Propofol; Thiopental sodium.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Consort flow diagram
Figure 2
Figure 2
Systolic blood pressure means (mmHg) of the participants during different anesthesia (A) and recovery (B) periods are shown. During anesthesia (A) an obvious difference is seen in minute 10, Also in recovery (B) during 0 and 5 minutes difference appears to be important but no intervals in this figure during separated times were significantly different
Figure 3
Figure 3
Diastolic blood pressure means (mmHg) of the participants during different anesthesia (A) and recovery (B) periods are shown. No significant difference during different intervals in separated times is seen
Figure 4
Figure 4
Pulse rate means (mmHg) of the participants during different anesthesia (A) and recovery (B) periods are shown. No significant difference during different intervals in separated times is seen
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Martin R, Tsen LC, Tzeng G, Hornstein MD, Datta S. Anesthesia for in vitro fertilization: the addition of fentanyl to 1.5% lidocaine. Anesth Analg. 1999;88:523–526. - PubMed
    1. Soussis I, Boyd O, Paraschos T, Duffy S, Bower S, Troughton P, et al. Follicular fluid levels of midazolam, fentanyl, and alfentanil during transvaginal oocyte retrieval. Fertil Steril. 1995;64:1003–1007. - PubMed
    1. Endler GC, Stout M, Magyar DM, Hayes MF, Moghissi KS, Sacco AG. Follicular fluid concentrations of thiopental and thiamylal during laparoscopy for oocyte retrieval. Fertil Steril. 1987;48:828–833. - PubMed
    1. Pierce ET, Smalky M, Alper MM, Hunter JA, Amrhein RL, Pierce EC Jr. Comparison of pregnancy rates following gamete intrafallopian transfer (GIFT) under general anesthesia with thiopental sodium or Propofol. J Clin Anesth. 1992;4:394–398. - PubMed
    1. Tramer MR, Moore RA, McQuay HJ. Propofol and bradycardia: causation, frequency and severity. Br J Anaesth. 1997;78:642–651. - PubMed

LinkOut - more resources