Probiotic administration attenuates myocardial hypertrophy and heart failure after myocardial infarction in the rat
- PMID: 24625365
- DOI: 10.1161/CIRCHEARTFAILURE.113.000978
Probiotic administration attenuates myocardial hypertrophy and heart failure after myocardial infarction in the rat
Abstract
Background: Probiotics are extensively used to promote gastrointestinal health, and emerging evidence suggests that their beneficial properties can extend beyond the local environment of the gut. Here, we determined whether oral probiotic administration can alter the progression of postinfarction heart failure.
Methods and results: Rats were subjected to 6 weeks of sustained coronary artery occlusion and administered the probiotic Lactobacillus rhamnosus GR-1 or placebo in the drinking water ad libitum. Culture and 16s rRNA sequencing showed no evidence of GR-1 colonization or a significant shift in the composition of the cecal microbiome. However, animals administered GR-1 exhibited a significant attenuation of left ventricular hypertrophy based on tissue weight assessment and gene expression of atrial natriuretic peptide. Moreover, these animals demonstrated improved hemodynamic parameters reflecting both improved systolic and diastolic left ventricular function. Serial echocardiography revealed significantly improved left ventricular parameters throughout the 6-week follow-up period including a marked preservation of left ventricular ejection fraction and fractional shortening. Beneficial effects of GR-1 were still evident in those animals in which GR-1 was withdrawn at 4 weeks, suggesting persistence of the GR-1 effects after cessation of therapy. Investigation of mechanisms showed a significant increase in the leptin:adiponectin plasma concentration ratio in rats subjected to coronary ligation, which was abrogated by GR-1. Metabonomic analysis showed differences between sham control and coronary artery ligated hearts particularly with respect to preservation of myocardial taurine levels.
Conclusions: The study suggests that probiotics offer promise as a potential therapy for the attenuation of heart failure.
Keywords: cardiomegaly; heart failure; microbiota; probiotics.
© 2014 American Heart Association, Inc.
Similar articles
-
Ginseng reverses established cardiomyocyte hypertrophy and postmyocardial infarction-induced hypertrophy and heart failure.Circ Heart Fail. 2012 Jul 1;5(4):504-14. doi: 10.1161/CIRCHEARTFAILURE.112.967489. Epub 2012 May 10. Circ Heart Fail. 2012. PMID: 22576957
-
Effects of hydrochlorothiazide on cardiac remodeling in a rat model of myocardial infarction-induced congestive heart failure.Eur J Pharmacol. 2011 Sep 30;667(1-3):314-21. doi: 10.1016/j.ejphar.2011.06.012. Epub 2011 Jun 17. Eur J Pharmacol. 2011. PMID: 21703256
-
Physiological replacement of T3 improves left ventricular function in an animal model of myocardial infarction-induced congestive heart failure.Circ Heart Fail. 2009 May;2(3):243-52. doi: 10.1161/CIRCHEARTFAILURE.108.810747. Epub 2009 Mar 25. Circ Heart Fail. 2009. PMID: 19808346
-
[Infarction expansion and ventricular remodelling after acute myocardial infarction].Ugeskr Laeger. 1993 Oct 25;155(43):3463-7. Ugeskr Laeger. 1993. PMID: 8256336 Review. Danish.
-
Left ventricular dilatation and failure post-myocardial infarction: pathophysiology and possible pharmacologic interventions.Cardiovasc Drugs Ther. 1990 Oct;4(5):1363-74. doi: 10.1007/BF02018264. Cardiovasc Drugs Ther. 1990. PMID: 2149059 Review.
Cited by
-
The Correlation Between Heart Failure and Gut Microbiome Metabolites.Infect Microbes Dis. 2020 Nov 4;2(4):136-143. doi: 10.1097/IM9.0000000000000042. eCollection 2020 Dec. Infect Microbes Dis. 2020. PMID: 38630083 Free PMC article. Review.
-
Probiotics ameliorate endocrine disorders via modulating inflammatory pathways: a systematic review.Genes Nutr. 2024 Mar 19;19(1):7. doi: 10.1186/s12263-024-00743-8. Genes Nutr. 2024. PMID: 38504163 Free PMC article. Review.
-
Prophylactic Supplementation with Lactobacillus Reuteri or Its Metabolite GABA Protects Against Acute Ischemic Cardiac Injury.Adv Sci (Weinh). 2024 May;11(18):e2307233. doi: 10.1002/advs.202307233. Epub 2024 Mar 15. Adv Sci (Weinh). 2024. PMID: 38487926 Free PMC article.
-
Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation.Gut Microbes. 2024 Jan-Dec;16(1):2323237. doi: 10.1080/19490976.2024.2323237. Epub 2024 Feb 27. Gut Microbes. 2024. PMID: 38411391 Free PMC article. Review.
-
Trends in gut-heart axis and heart failure research (1993-2023): A bibliometric and visual analysis.Heliyon. 2024 Feb 7;10(4):e25995. doi: 10.1016/j.heliyon.2024.e25995. eCollection 2024 Feb 29. Heliyon. 2024. PMID: 38404792 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical