Fibroblast-myocyte electrotonic coupling: does it occur in native cardiac tissue?
- PMID: 24412581
- PMCID: PMC4001130
- DOI: 10.1016/j.yjmcc.2013.12.024
Fibroblast-myocyte electrotonic coupling: does it occur in native cardiac tissue?
Abstract
Heterocellular electrotonic coupling between cardiac myocytes and non-excitable connective tissue cells has been a long-established and well-researched fact in vitro. Whether or not such coupling exists in vivo has been a matter of considerable debate. This paper reviews the development of experimental insight and conceptual views on this topic, describes evidence in favour of and against the presence of such coupling in native myocardium, and identifies directions for further study needed to resolve the riddle, perhaps less so in terms of principal presence which has been demonstrated, but undoubtedly in terms of extent, regulation, patho-physiological context, and actual relevance of cardiac myocyte-non-myocyte coupling in vivo. This article is part of a Special Issue entitled "Myocyte-Fibroblast Signalling in Myocardium."
Keywords: Connective tissue; Electrophysiology; Fibrosis; Gap junction; Heart; Scar.
Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.
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References
-
- Camelliti P., Borg T.K., Kohl P. Structural and functional characterisation of cardiac fibroblasts. Cardiovasc Res. 2005;65:40–51. - PubMed
-
- Fujiu K., Nagai R. Contributions of cardiomyocyte-cardiac fibroblast-immune cell interactions in heart failure development. Basic Res Cardiol. 2013;108:357. - PubMed
-
- Yamazaki K.G., Gonzalez E., Zambon A.C. Crosstalk between the renin-angiotensin system and the advance glycation end product axis in the heart: role of the cardiac fibroblast. J Cardiovasc Transl Res. 2012;5:805–813. - PubMed
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