90Y radioembolization versus chemoembolization in the treatment of hepatocellular carcinoma: an analysis of comparative effectiveness
- PMID: 24236684
- DOI: 10.2217/cer.13.37
90Y radioembolization versus chemoembolization in the treatment of hepatocellular carcinoma: an analysis of comparative effectiveness
Abstract
Locoregional catheter-based therapies for unresectable hepatocellular carcinoma (HCC) include conventional transarterial chemoembolization (cTACE), drug-eluting bead chemoembolization and yttrium-90 ((90)Y) radioembolization. Although current guidelines recommend cTACE for inoperable HCC, comparative effectiveness of drug-eluting bead chemoembolization and (90)Y radioembolization in the management of HCC remains undefined due to the lack of data evaluating safety and effectiveness among these therapies. A comprehensive search of the literature was carried out for studies examining comparative effectiveness of cTACE and (90)Y based on objective tumor response and overall patient survival. Further data on efficacy, safety, toxicity and cost-effectiveness was also examined. The National Cancer Institute Levels of Evidence for Cancer Treatment Studies provided a useful framework for the critical understanding and stratification of current evidence on locoregional therapy for unresectable HCC. Based on current retrospective cohort studies, evidence for similar efficacy and safety between cTACE and (90)Y radioembolization was demonstrated. Further prospective, randomized studies are required to validate these observations and to analyze cost-effectiveness of these interventions in unresectable HCC patients for definitive recommendations to be made.
Similar articles
-
Meta-analysis: adjusted indirect comparison of drug-eluting bead transarterial chemoembolization versus 90Y-radioembolization for hepatocellular carcinoma.Eur Radiol. 2017 May;27(5):2031-2041. doi: 10.1007/s00330-016-4548-3. Epub 2016 Aug 25. Eur Radiol. 2017. PMID: 27562480
-
Cost effectiveness of radioembolization compared with conventional transarterial chemoembolization for treatment of hepatocellular carcinoma.J Vasc Interv Radiol. 2014 Jul;25(7):1075-84. doi: 10.1016/j.jvir.2014.04.014. Epub 2014 May 24. J Vasc Interv Radiol. 2014. PMID: 24861664 Review.
-
Comparison of the survival and tolerability of radioembolization in elderly vs. younger patients with unresectable hepatocellular carcinoma.J Hepatol. 2013 Oct;59(4):753-61. doi: 10.1016/j.jhep.2013.05.025. Epub 2013 May 23. J Hepatol. 2013. PMID: 23707371 Clinical Trial.
-
Transarterial radioembolization versus chemoembolization for the treatment of hepatocellular carcinoma (TRACE): study protocol for a randomized controlled trial.Trials. 2012 Aug 23;13:144. doi: 10.1186/1745-6215-13-144. Trials. 2012. PMID: 22913492 Free PMC article. Clinical Trial.
-
(90)Y-glass microspheres for hepatic neoplasia.Future Oncol. 2015;11(9):1343-54. doi: 10.2217/fon.15.12. Future Oncol. 2015. PMID: 25952780 Review.
Cited by
-
The Role of 18F-FLT PET/CT in Assessing Early Response to Transarterial Radioembolization and Chemoembolization in Patients with Primary and Metastatic Liver Tumors.Mol Imaging Radionucl Ther. 2022 Oct 19;31(3):207-215. doi: 10.4274/mirt.galenos.2022.85579. Mol Imaging Radionucl Ther. 2022. PMID: 36268887 Free PMC article.
-
Yttrium-90 transarterial radioembolization versus conventional transarterial chemoembolization for patients with hepatocellular carcinoma: a systematic review and meta-analysis.Cancer Biol Med. 2018 Aug;15(3):299-310. doi: 10.20892/j.issn.2095-3941.2017.0177. Cancer Biol Med. 2018. PMID: 30197797 Free PMC article.
-
Meta-analysis: adjusted indirect comparison of drug-eluting bead transarterial chemoembolization versus 90Y-radioembolization for hepatocellular carcinoma.Eur Radiol. 2017 May;27(5):2031-2041. doi: 10.1007/s00330-016-4548-3. Epub 2016 Aug 25. Eur Radiol. 2017. PMID: 27562480
-
Transarterial Radioembolization with Yttrium-90 for the Treatment of Hepatocellular Carcinoma.Adv Ther. 2016 May;33(5):699-714. doi: 10.1007/s12325-016-0324-7. Epub 2016 Apr 2. Adv Ther. 2016. PMID: 27039186 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical