Cutaneous squamous cell carcinomas of the lower extremity: a distinct subset of squamous cell carcinomas
- PMID: 24210370
- DOI: 10.1016/j.jaad.2013.09.026
Cutaneous squamous cell carcinomas of the lower extremity: a distinct subset of squamous cell carcinomas
Abstract
Background: Some patients develop a disproportionate number of cutaneous squamous cell carcinomas (SCCs) on their lower extremity (LE).
Objective: We sought to characterize the clinical features, treatment, and outcome in patients who develop multiple LE SCCs.
Methods: We identified 22 patients with 4 or more biopsy-diagnosed LE SCCs during a 4.5-year study period. The location, size, treatment, and clinical outcome of each LE SCC were recorded.
Results: Of the 22 patients studied, 18 were female. Of the 360 SCCs our patients developed, 260 (72.2%) were on the LE. The incidence of SCCs in these patients was nearly 7 times greater than the incidence of basal cell carcinoma in the same patients.
Limitations: The number of patients is small and limits definitive conclusions about prevalence of SCCs on the LE in the general population.
Conclusions: LE SCCs are a distinct subset of cutaneous SCCs and may have distinctive clinical features and biologic behavior requiring additional study.
Keywords: BCC; LE; MCS; Mohs microscopically controlled surgery; SCC; UV; basal cell carcinoma; carcinogen; epidemiology; female; immunosuppression; leg; lower extremity; squamous cell carcinoma; ultraviolet; ultraviolet radiation.
Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
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