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Comparative Study
. 2014 Sep;44(9):1685-91.
doi: 10.1007/s00595-013-0748-5. Epub 2013 Oct 16.

Difference in the recurrence rate between right- and left-sided colon cancer: a 17-year experience at a single institution

Konosuke Moritani  1 , Hirotoshi Hasegawa, Koji Okabayashi, Yoshiyuki Ishii, Takashi Endo, Yuko Kitagawa
Affiliations
Comparative Study

Difference in the recurrence rate between right- and left-sided colon cancer: a 17-year experience at a single institution

Konosuke Moritani et al. Surg Today. 2014 Sep.

Abstract

Purpose: The prognostic differences between right- and left-sided colon cancer are controversial. This study aimed to clarify the clinical difference between right- and left-sided colon cancer.

Methods: We enrolled 820 patients with stage I/II/III colon cancer who underwent radical surgery with curative intent. We explored the impact of the tumor location on the postoperative disease-free survival (DFS) rate using the univariate and multivariate analyses.

Results: Right-sided disease occurred in 399 of the 820 patients. The mean follow-up period was 55.8 ± 34.9 months. The pathological stage distribution was as follows: stage I 261 patients; stage II 283; and stage III 251. There were no significant differences in the five-year DFS of the overall populations (right 88.6%; left 89.4%; P = 0.231). The subgroup analyses demonstrated that patients with stage I right-sided colon cancer had a significantly better 5-year DFS rate than did those with left-sided disease (100 vs. 95.2%, P = 0.034). There were no significant differences in the distributions of the first recurrent sites (P = 0.559).

Conclusions: The tumor location may contribute to postoperative tumor recurrence. However, these effects were inconsistent across tumor stages. Our results provide a better understanding of the prognostic disparity between tumor locations; this may improve patient consent and postoperative surveillance.

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Figures

Fig. 1
Fig. 1
A flow chart of the patient inclusions between January 1990 and January 2006
Fig. 2
Fig. 2
The five-year disease-free survival rate of patients with right- and left-sided colon cancer. There was no significant difference between right- and left-sided disease (right 85.2 %; left 88.4 %; P = 0.231)
Fig. 3
Fig. 3
The five-year disease-free survival rate of patients with right- and left-sided colon cancer in stage I. Patients with right-sided colon cancer had a significantly better survival rate (100 vs. 95.2 %, P = 0.034)
Fig. 4
Fig. 4
The five-year disease-free survival rate of patients with right- and left-sided colon cancer in stages II/III. There was no significant difference between right- and left-sided disease (right 79.4 %; left 84.7 %; P = 0.152)
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