The growth of human scalp hair mediated by visible red light laser and LED sources in males
- PMID: 24078483
- DOI: 10.1002/lsm.22173
The growth of human scalp hair mediated by visible red light laser and LED sources in males
Erratum in
- Lasers Surg Med. 2014 Apr;46(4):373
Abstract
Background and objectives: Low level laser therapy (LLLT) has been used to promote hair growth. A double-blind randomized controlled trial was undertaken to define the safety and physiologic effects of LLLT on males with androgenic alopecia.
Methods: Forty-four males (18-48 yo, Fitzpatrick I-IV, Hamilton-Norwood IIa-V) were recruited. A transition zone scalp site was selected; hairs were trimmed to 3 mm height; the area was tattooed and photographed. The active group received a "TOPHAT655" unit containing 21, 5 mW lasers (655 ± 5 nm), and 30 LEDS (655 ± 20 nm), in a bicycle-helmet like apparatus. The placebo group unit appeared identical, containing incandescent red lights. Patients treated at home every other day × 16 weeks (60 treatments, 67.3 J/cm(2) irradiance/25 minute treatment), with follow up and photography at 16 weeks. A masked 2.85 cm(2) photographic area was evaluated by another blinded investigator. The primary endpoint was the percent increase in hair counts from baseline.
Results: Forty-one patients completed the study (22 active, 19 placebo). No adverse events or side effects were reported. Baseline hair counts were 162.7 ± 95.9 (N = 22) in placebo and 142.0 ± 73.0 (N = 22) and active groups respectively (P = 0.426). Post Treatment hair counts were 162.4 ± 62.5 (N = 19) and 228.7 ± 102.8 (N = 22), respectively (P = 0.0161). A 39% percent hair increase was demonstrated (28.4 ± 46.2 placebo, N = 19; 67.2 ± 33.4, active, N = 22) (P = 0.001) Deleting one placebo group subject with a very high baseline count and a very large decrease, resulted in baseline hair counts of 151.1 ± 81.0 (N = 21) and 142.0 ± 73.0 (N = 22), respectively (P = 0.680). Post treatment hair counts were 158.2 ± 61.5 (N = 18) and 228.7 ± 102.8 (N = 22) (P = 0.011), resulting in a 35% percent increase in hair growth (32.3 ± 44.2, placebo, N = 18; 67.2 ± 33.4, active, N = 22) (P = 0.003).
Conclusions: LLLT of the scalp at 655 nm significantly improved hair counts in males with androgenetic alopecia.
Trial registration: ClinicalTrials.gov NCT01437163.
Keywords: Alopecia; LED; RCT; clinical research; hair; human, laser; low level laser therapy (LLLT); photobiomodulation.
© 2013 Wiley Periodicals, Inc.
Similar articles
-
The growth of human scalp hair in females using visible red light laser and LED sources.Lasers Surg Med. 2014 Oct;46(8):601-7. doi: 10.1002/lsm.22277. Epub 2014 Aug 13. Lasers Surg Med. 2014. PMID: 25124964 Free PMC article. Clinical Trial.
-
Low-level light therapy for androgenetic alopecia: a 24-week, randomized, double-blind, sham device-controlled multicenter trial.Dermatol Surg. 2013 Aug;39(8):1177-83. doi: 10.1111/dsu.12200. Epub 2013 Apr 3. Dermatol Surg. 2013. PMID: 23551662 Clinical Trial.
-
Low-level laser therapy for the treatment of androgenetic alopecia in Thai men and women: a 24-week, randomized, double-blind, sham device-controlled trial.Lasers Med Sci. 2019 Aug;34(6):1107-1114. doi: 10.1007/s10103-018-02699-9. Epub 2018 Dec 19. Lasers Med Sci. 2019. PMID: 30569416 Clinical Trial.
-
Low-level laser therapy for the treatment of androgenic alopecia: a review.Lasers Med Sci. 2018 Feb;33(2):425-434. doi: 10.1007/s10103-017-2385-5. Epub 2017 Dec 21. Lasers Med Sci. 2018. PMID: 29270707 Review.
-
Low-level laser therapy as a treatment for androgenetic alopecia.Lasers Surg Med. 2017 Jan;49(1):27-39. doi: 10.1002/lsm.22512. Epub 2016 Apr 25. Lasers Surg Med. 2017. PMID: 27114071 Review.
Cited by
-
Efficacy of Low-Level Laser Versus Topical Erythromycin 2% in the Treatment of Inflammatory Acne Vulgaris.Dermatol Pract Concept. 2024 Apr 1;14(2):e2024048. doi: 10.5826/dpc.1402a48. Dermatol Pract Concept. 2024. PMID: 38810082 Free PMC article.
-
Effect of Skin Type on Efficacy of Laser Treatment for Androgenetic Alopecia: A Review of the Literature.Skin Appendage Disord. 2023 Oct;9(5):317-324. doi: 10.1159/000528518. Epub 2023 Jul 3. Skin Appendage Disord. 2023. PMID: 37900781 Review.
-
Combination and Rotational Therapy in Androgenetic Alopecia.J Cutan Aesthet Surg. 2023 Apr-Jun;16(2):71-80. doi: 10.4103/JCAS.JCAS_212_22. J Cutan Aesthet Surg. 2023. PMID: 37554681 Free PMC article.
-
Efficacy of Low-Level Laser Therapy in Androgenetic Alopecia - A Randomized Controlled Trial.Int J Trichology. 2023 Jan-Feb;15(1):25-32. doi: 10.4103/ijt.ijt_5_22. Epub 2023 Apr 19. Int J Trichology. 2023. PMID: 37305186 Free PMC article.
-
Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming?Curr Oncol. 2023 Mar 25;30(4):3609-3626. doi: 10.3390/curroncol30040275. Curr Oncol. 2023. PMID: 37185388 Free PMC article. Review.
Publication types
MeSH terms
Associated data
LinkOut - more resources
Full Text Sources
Other Literature Sources