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. 2013 Dec;16(6):475-82.
doi: 10.1007/s00737-013-0371-x. Epub 2013 Aug 10.

Elevated risk of adverse obstetric outcomes in pregnant women with depression

Deborah R Kim  1 , Laura E Sockol, Mary D Sammel, Caroline Kelly, Marian Moseley, C Neill Epperson
Affiliations

Elevated risk of adverse obstetric outcomes in pregnant women with depression

Deborah R Kim et al. Arch Womens Ment Health. 2013 Dec.

Abstract

In this study, we evaluated the association between prenatal depression symptoms adverse birth outcomes in African-American women. We conducted a retrospective cohort study of 261 pregnant African-American women who were screened with the Edinburgh Postnatal Depression Scale (EPDS) at their initial prenatal visit. Medical records were reviewed to assess pregnancy and neonatal outcomes, specifically preeclampsia, preterm birth, intrauterine growth retardation, and low birth weight. Using multivariable logistic regression models, an EPDS score ≥10 was associated with increased risk for preeclampsia, preterm birth, and low birth weight. An EPDS score ≥10 was associated with increased risk for intrauterine growth retardation, but after controlling for behavioral risk factors, this association was no longer significant. Patients who screen positive for depression symptoms during pregnancy are at increased risk for multiple adverse birth outcomes. In a positive, patient-rated depression screening at the initial obstetrics visit, depression is associated with increased risk for multiple adverse birth outcomes. Given the retrospective study design and small sample size, these findings should be confirmed in a prospective cohort study.

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References

    1. Andersson L, Sundström-Poromaa I, Wulff M, Aström M, Bixo M. Implications of antenatal depression and anxiety for obstetric outcome. Obstet Gynecol. 2004 Sep;104(3):467–76. - PubMed
    1. Bonari L, Pinto N, Ahn E, Einarson A, Steiner M, Koren G. Perinatal risks of untreated depression during pregnancy. Can J Psychiatry. 2004;49:726–35. - PubMed
    1. Chen CH, Lin HC. Prenatal care and adverse pregnancy outcomes among women with depression: A nationwide population-based study. Can J Psychiatry. 2011;56:273–80. - PubMed
    1. Cox JL, Chapman G, Murray D, Jones P. Validation of the edinburgh postnatal depression scale (EPDS) in non-postnatal women. J Affect Disord. 1996;39:185–9. - PubMed
    1. Cripe SM, Frederick IO, Qiu C, Williams MA. Risk of preterm delivery and hypertensive disorders of pregnancy in relation to maternal co-morbid mood and migraine disorders during pregnancy. Paediatr Perinat Epidemiol. 2011 Mar;25(2):116–23. - PMC - PubMed

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