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. 2013 Jun 18;110 Suppl 2(Suppl 2):10402-7.
doi: 10.1073/pnas.1301209110. Epub 2013 Jun 10.

Making lasting memories: remembering the significant

James L McGaugh  1
Affiliations

Making lasting memories: remembering the significant

James L McGaugh. Proc Natl Acad Sci U S A. .

Abstract

Although forgetting is the common fate of most of our experiences, much evidence indicates that emotional arousal enhances the storage of memories, thus serving to create, selectively, lasting memories of our more important experiences. The neurobiological systems mediating emotional arousal and memory are very closely linked. The adrenal stress hormones epinephrine and corticosterone released by emotional arousal regulate the consolidation of long-term memory. The amygdala plays a critical role in mediating these stress hormone influences. The release of norepinephrine in the amygdala and the activation of noradrenergic receptors are essential for stress hormone-induced memory enhancement. The findings of both animal and human studies provide compelling evidence that stress-induced activation of the amygdala and its interactions with other brain regions involved in processing memory play a critical role in ensuring that emotionally significant experiences are well-remembered. Recent research has determined that some human subjects have highly superior autobiographic memory of their daily experiences and that there are structural differences in the brains of these subjects compared with the brains of subjects who do not have such memory. Understanding of neurobiological bases of such exceptional memory may provide additional insights into the processes underlying the selectivity of memory.

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Conflict of interest statement

The author declares no conflict of interest.

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References

    1. Glore J. Personal Arts. 1987. (SCR Theatre, Costa Mesa, CA), Vol 2.
    1. Bernecker S. Memory. Oxford: Oxford Univ Press; 2010.
    1. James W. Principles of Psychology. New York: Henry Holt and Company; 1890.
    1. Craik FIM, Lockhart RS. Levels of processing: A framework for memory research. J Verbal Learn and Verbal Behav. 1972;11:671–684.
    1. Ebbinghaus H. Uber das Gedachtnis. Leipzig, Germany: Drucker and Humblat; 1885.

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