Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes
- PMID: 23732518
- DOI: 10.1016/j.freeradbiomed.2013.05.035
Role of oxidants on calcium and sodium movement in healthy and diseased cardiac myocytes
Abstract
In this review article we give an overview of current knowledge with respect to redox-sensitive alterations in Na(+) and Ca(2+) handling in the heart. In particular, we focus on redox-activated protein kinases including cAMP-dependent protein kinase A (PKA), protein kinase C (PKC), and Ca/calmodulin-dependent protein kinase II (CaMKII), as well as on redox-regulated downstream targets such as Na(+) and Ca(2+) transporters and channels. We highlight the pathological and physiological relevance of reactive oxygen species and some of its sources (such as NADPH oxidases, NOXes) for excitation-contraction coupling (ECC). A short outlook with respect to the clinical relevance of redox-dependent Na(+) and Ca(2+) imbalance will be given.
Keywords: (late), late Na(+) current; A-kinase anchor protein; AKAP; AP; APD; Ang II; BH4; Ca handling; Ca/calmodulin-dependent protein kinase II; CaM; CaMKII; CaMKIIδ(C); Calcium; Coupling; DAD; DAG; DCM; DOX; EAD; ECC; ER; ETC; Exciation—contraction; FKBP12.6; GSH; HF; HFpEF; HFrEF; I(Ca); I(Na); I(Ti); I(to); L-type Ca(2+) channels; LTCC; Late Na current; MPT; NADH; NADPH; NADPH oxidase; NCX1; NHE; NKA; NO; NOS; NOS1; NOS2; NOS3; NOX; Na(+) channel protein; Na(+)/H(+) exchanger; NaV1.5; ONOO(-); PKA; PKC; PLB; PLM; PPI-1; ROS; RyR2; SERCA2a; SOD; SR; SR Ca leak; Sodium; Trx; XOR; action potential; action potential duration; angiotensin II; cAMP; cAMP-dependent protein kinase A; calmodulin; calstabin; cyclic adenosine monophosphate; cytosolic splice variant of Ca/calmodulin-dependent protein kinase II; delayed afterdepolarization; diacylglycerol; dilated cardiomyopathy; doxorubicin; early afterdepolarizations; electron transport chain in the mitochondria; endoplasmic reticulum; endothelial nitric oxide synthase (also eNOS); excitation-contraction coupling; gluthathione; heart failure; heart failure with preserved ejection fraction; heart failure with reduced ejection fraction; inducible nitric oxide synthase (also iNOS); inward Ca(2+) current; inward Na(+) current; mitochondrial permeability transition; neuronal nitric oxide synthase (also nNOS); nicotinamide adenine dinucleotide; nicotinamide adenine dinucleotide phosphate; nitric oxide; nitric oxide synthase; outward rectifying K(+) currents; peroxynitrite; phospholamban; phospholemman; protein kinase C; protein phosphatase inhibitor 1; reactive oxygen species; ryanodine receptors; sarcolemmal Na(+)/Ca(2+) exchanger; sarcolemmal Na(+)/K(+) ATPase; sarcoplasmic reticulum; sarcoplasmic reticulum Ca(2+)-ATPase; superoxide dismutase; tetrahydrobiopterin; thioredoxin; transient inward current; xanthine oxidase.
Copyright © 2013 Elsevier Inc. All rights reserved.
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