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Review
. 2013 Aug;84(2):102-8.
doi: 10.1111/cge.12180. Epub 2013 Jun 10.

Genetic susceptibility and mechanisms for refractive error

D Stambolian  1
Affiliations
Review

Genetic susceptibility and mechanisms for refractive error

D Stambolian. Clin Genet. 2013 Aug.

Abstract

Refractive errors, myopia and hyperopia, are the most common causes of visual impairment worldwide. Recent advances in genetics have been utilized to identify a wealth of genetic loci believed to contain susceptibility genes for refractive error (RE). The current genetic evidence confirms that RE is influenced by both common and rare variants with a significant environmental component. These studies argue that only by combining genetic and environmental knowledge with in vivo measurements of biological states will it be possible to understand the underlying biology of RE that will lead to novel therapeutic targets and accurate genetic predictions.

Keywords: animal models; gene-environment interaction; genetic variation; hyperopia; myopia; refractive error.

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Conflict of interest statement

The author has no potential conflicts.

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