Evaluation of HER2-based biology in 1,006 cases of gastric cancer in a Japanese population
- PMID: 23430266
- DOI: 10.1007/s10120-013-0239-9
Evaluation of HER2-based biology in 1,006 cases of gastric cancer in a Japanese population
Abstract
Background: The ToGA trial demonstrated the beneficial effect of trastuzumab in gastric cancer patients with human epidermal growth factor receptor 2 (HER2)-overexpressing tumors. Therefore, evaluation of the relationship between HER2 expression and gastric cancer biology using a validated system has become an even more important task. Herein, we verified the correlation between HER2 overexpression in the tumor and the clinical course of gastric cancer patients.
Methods: A total of 1,006 consecutive patients with gastric cancer who underwent surgery at the National Cancer Center Hospital East between January 2003 and July 2007 were examined using the tissue microarrays approach. HER2 expression was determined based on an immunohistochemistry score of 3+, or an immunohistochemistry score of 2+ plus HER2 gene amplification as detected by double-color fluorescent in situ hybridization. A retrospective review of the medical records was conducted to determine the correlation between the presence of HER2 overexpression and clinicopathological factors. Then, in 948 patients who had undergone curative resection, HER2 status was compared with the survival.
Results: HER2 overexpression was detected in 118 (11.7 %) patients. HER2 overexpression was correlated with age, gender, grade of differentiation, expanding growth pattern, and nodal status. In the survival analysis, HER2 overexpression was not found to be correlated with either disease-specific survival or recurrence-free survival.
Conclusions: HER2 overexpression in the tumor was not identified as a significant prognostic factor in patients with operable gastric cancer. The HER2-targeted therapy may be beneficial in a proportion of cases.
Similar articles
-
The clinicopathological parameters and prognostic significance of HER2 expression in gastric cancer patients: a meta-analysis of literature.World J Surg Oncol. 2017 Mar 21;15(1):68. doi: 10.1186/s12957-017-1132-5. World J Surg Oncol. 2017. PMID: 28327158 Free PMC article. Review.
-
Correlation of human epidermal growth factor receptor 2 expression with clinicopathological characteristics and prognosis in gastric cancer.World J Gastroenterol. 2013;19(14):2171-8. doi: 10.3748/wjg.v19.i14.2171. World J Gastroenterol. 2013. PMID: 23599643 Free PMC article.
-
HER2/neu gene amplification and protein overexpression in gastric and gastroesophageal junction adenocarcinoma: a review of histopathology, diagnostic testing, and clinical implications.Arch Pathol Lab Med. 2012 Jun;136(6):691-7. doi: 10.5858/arpa.2011-0168-RS. Arch Pathol Lab Med. 2012. PMID: 22646280 Review.
-
HER2 expression and its clinicopathological features in resectable gastric cancer.Gastric Cancer. 2013 Jan;16(1):84-93. doi: 10.1007/s10120-012-0150-9. Epub 2012 Mar 14. Gastric Cancer. 2013. PMID: 22410801
-
Human epidermal growth factor receptor-2 gene amplification in gastric cancer using tissue microarray technology.World J Gastroenterol. 2012 Jan 14;18(2):150-5. doi: 10.3748/wjg.v18.i2.150. World J Gastroenterol. 2012. PMID: 22253521 Free PMC article.
Cited by
-
Recent Progress in Treatment for HER2-Positive Advanced Gastric Cancer.Cancers (Basel). 2024 Apr 30;16(9):1747. doi: 10.3390/cancers16091747. Cancers (Basel). 2024. PMID: 38730700 Free PMC article. Review.
-
Phase 1 multicenter, dose-expansion study of ARX788 as monotherapy in HER2-positive advanced gastric and gastroesophageal junction adenocarcinoma.Cell Rep Med. 2022 Nov 15;3(11):100814. doi: 10.1016/j.xcrm.2022.100814. Cell Rep Med. 2022. PMID: 36384091 Free PMC article. Clinical Trial.
-
Tumor Characteristics Associated with Lymph Node Metastasis and Prognosis in Patients with ERBB2-Positive Gastric Cancer.J Oncol. 2022 Aug 25;2022:7592046. doi: 10.1155/2022/7592046. eCollection 2022. J Oncol. 2022. PMID: 36059809 Free PMC article.
-
Active Stat3 and Her-2 as combined survival predictors show superiority to TNM staging system for postoperative patients with gastric cancer.Am J Transl Res. 2022 Apr 15;14(4):2317-2330. eCollection 2022. Am J Transl Res. 2022. PMID: 35559376 Free PMC article.
-
The Clinical Significance and Prognostic Value of HER2 Expression in Bladder Cancer: A Meta-Analysis and a Bioinformatic Analysis.Front Oncol. 2021 Sep 1;11:653491. doi: 10.3389/fonc.2021.653491. eCollection 2021. Front Oncol. 2021. PMID: 34540657 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous