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Case Reports
. 2012 Nov 8;367(19):1814-20.
doi: 10.1056/NEJMoa1211721. Epub 2012 Oct 17.

Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

Ali M Zaki  1 , Sander van Boheemen, Theo M Bestebroer, Albert D M E Osterhaus, Ron A M Fouchier
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Free article
Case Reports

Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

Ali M Zaki et al. N Engl J Med. .
Free article

Erratum in

  • N Engl J Med. 2013 Jul 25;369(4):394

Abstract

A previously unknown coronavirus was isolated from the sputum of a 60-year-old man who presented with acute pneumonia and subsequent renal failure with a fatal outcome in Saudi Arabia. The virus (called HCoV-EMC) replicated readily in cell culture, producing cytopathic effects of rounding, detachment, and syncytium formation. The virus represents a novel betacoronavirus species. The closest known relatives are bat coronaviruses HKU4 and HKU5. Here, the clinical data, virus isolation, and molecular identification are presented. The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.

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