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. 2012 Aug;15(Suppl 1):S15-22.
doi: 10.4103/0972-2327.99993.

Pathophysiology of migraine

Affiliations

Pathophysiology of migraine

Peter J Goadsby. Ann Indian Acad Neurol. 2012 Aug.

Abstract

Migraine is a common disabling brain disorder whose pathophysiology is now being better understood. The study of anatomy and physiology of pain producing structures in the cranium and the central nervous system modulation of the input have led to the conclusion that migraine involves alterations in the sub-cortical aminergic sensory modulatory systems that influence the brain widely.

Keywords: Brainstem; dyshabituation; migraine.

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Conflict of interest statement

Conflict of Interest: Nil

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References

    1. Goadsby PJ, Lipton RB, Ferrari MD. Migraine- current understanding and treatment. N Engl J Med. 2002;346:257–70. - PubMed
    1. Goadsby PJ, Charbit AR, Andreou AP, Akerman S, Holland PR. Neurobiology of migraine. Neuroscience. 2009;161:327–41. - PubMed
    1. van den Maagdenberg AM, Haan J, Terwindt GM, Ferrari MD. Migraine: Gene mutations and functional consequences. Curr Opin Neurol. 2007;20:299–305. - PubMed
    1. Russell MB, Iselius L, Olesen J. Investigation of the inheritance of migraine by complex segregation analysis. Hum Genet. 1995;96:726–30. - PubMed
    1. Scher AI, Terwindt GM, Verschuren WM, Kruit MC, Blom HJ, Kowa H, et al. Migraine and MTHFR C677T genotype in a population-based sample. Ann Neurol. 2006;59:372–5. - PubMed