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Review
. 2012 Jul;52(1):16-21.
doi: 10.1016/j.ceca.2012.04.006. Epub 2012 Jun 4.

The mitochondrial Ca(2+) uniporter

Anna Raffaello  1 , Diego De Stefani, Rosario Rizzuto
Affiliations
Review

The mitochondrial Ca(2+) uniporter

Anna Raffaello et al. Cell Calcium. 2012 Jul.

Abstract

Mitochondrial Ca(2+) uptake plays a fundamental role in the regulation of energy production and cell survival. Under physiological conditions, mitochondrial Ca(2+) uptake occurs by a uniport mechanism driven electrophoretically by the membrane potential created by the respiratory chain. The activity and the biochemical properties of the mitochondrial calcium uniporter (MCU) were extensively characterized for decades but the molecular identity of the channel has remained elusive. Here, we review the recent discovery of the mitochondria Ca(2+) uniporter that represents a groundbreaking result for the molecular understanding of mitochondrial Ca(2+) homeostasis and will provide insight into the role of mitochondrial Ca(2+) deregulation in the pathogenesis of human disorders.

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