Pregnancy outcome following exposure to topical retinoids: a multicenter prospective study
- PMID: 22174426
- DOI: 10.1177/0091270011429566
Pregnancy outcome following exposure to topical retinoids: a multicenter prospective study
Abstract
Concerns have been raised about the use of topical retinoids since the publication of isolated cases of characteristic retinoid embryopathy, originally described after oral use. A collaborative study of the European Network of Teratology Information Services was carried out to evaluate the rate of congenital malformations following first-trimester topical retinoid exposure. A population of 235 exposed pregnant women was compared with 444 controls. No significant differences were observed between groups with regard to the rates of spontaneous abortion (odds ratio [95% confidence interval], 1.5 [0.8-2.7]), minor birth defects (1.3 [0.4-3.7]), and major birth defects (1.8 [0.6-5.4]). No child showed features of retinoid embryopathy. The rate of elective termination in the exposed group was increased 3-fold (3.4 [1.5-7.8]). In conclusion, these results do not suggest an increased risk of retinoid embryopathy. However, according to current knowledge, topical retinoids cannot be advised for use during pregnancy because their risk/benefit ratio remains questionable.
Similar articles
-
Pregnancy outcomes following first-trimester exposure to topical retinoids: a systematic review and meta-analysis.Br J Dermatol. 2015 Nov;173(5):1132-41. doi: 10.1111/bjd.14053. Epub 2015 Oct 19. Br J Dermatol. 2015. PMID: 26215715 Review.
-
Pregnancy outcome following maternal exposure to statins: a multicentre prospective study.BJOG. 2013 Mar;120(4):463-71. doi: 10.1111/1471-0528.12066. Epub 2012 Nov 30. BJOG. 2013. PMID: 23194157
-
Vitamin K antagonists and pregnancy outcome. A multi-centre prospective study.Thromb Haemost. 2006 Jun;95(6):949-57. doi: 10.1160/TH06-02-0108. Thromb Haemost. 2006. PMID: 16732373
-
Pregnancy outcome after methotrexate treatment for rheumatic disease prior to or during early pregnancy: a prospective multicenter cohort study.Arthritis Rheumatol. 2014 May;66(5):1101-10. doi: 10.1002/art.38368. Arthritis Rheumatol. 2014. PMID: 24470106
-
Post-marketing surveillance system for drugs in pregnancy--15 years experience of ENTIS.Reprod Toxicol. 2005 Sep-Oct;20(3):331-43. doi: 10.1016/j.reprotox.2005.03.012. Reprod Toxicol. 2005. PMID: 15978773 Review.
Cited by
-
Management of Acne in Pregnancy.Am J Clin Dermatol. 2024 May;25(3):465-471. doi: 10.1007/s40257-024-00851-6. Epub 2024 Mar 7. Am J Clin Dermatol. 2024. PMID: 38453786 Review.
-
Impact of the 2018 revised Pregnancy Prevention Programme by the European Medicines Agency on the use of oral retinoids in females of childbearing age in Denmark, Italy, Netherlands, and Spain: an interrupted time series analysis.Front Pharmacol. 2023 Aug 17;14:1207976. doi: 10.3389/fphar.2023.1207976. eCollection 2023. Front Pharmacol. 2023. PMID: 37663263 Free PMC article.
-
Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations.Adv Ther. 2022 Dec;39(12):5351-5375. doi: 10.1007/s12325-022-02319-7. Epub 2022 Oct 11. Adv Ther. 2022. PMID: 36220974 Free PMC article. Review.
-
Skin Changes and Safety Profile of Topical Products During Pregnancy.J Clin Aesthet Dermatol. 2022 Feb;15(2):49-57. J Clin Aesthet Dermatol. 2022. PMID: 35309882 Free PMC article. Review.
-
Retinoic Acid and Its Derivatives in Skin.Cells. 2020 Dec 11;9(12):2660. doi: 10.3390/cells9122660. Cells. 2020. PMID: 33322246 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical