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. 2012 Apr;74(4):507-11.
doi: 10.1292/jvms.11-0274. Epub 2011 Nov 25.

Minimum alveolar concentration for blunting adrenergic responses (MAC-BAR) of sevoflurane in dogs

Kazuto Yamashita  1 , Erika Furukawa, Takaharu Itami, Tomohito Ishizuka, Jun Tamura, Kenjirou Miyoshi
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Free article

Minimum alveolar concentration for blunting adrenergic responses (MAC-BAR) of sevoflurane in dogs

Kazuto Yamashita et al. J Vet Med Sci. 2012 Apr.
Free article

Abstract

It is well known that heart rate or arterial blood pressure may increase in response to surgical stimulation despite the absence of a purposeful movement. However, there is limited information regarding anesthetic requirement for blunting adrenergic response in dogs. This study was designed to compare the minimum alveolar concentrations of sevoflurane required to prevent autonomic response (MAC-BAR) and purposeful movement (MAC) in dogs. Sevoflurane MAC-BAR and MAC were determined in 5 beagle dogs by judging dogs' response to a noxious electrical stimulus applied to the gingiva. The sevoflurane MAC-BAR was significantly higher than MAC (3.33 ± 0.48 vs 2.10 ± 0.28%, P=0.005). These results suggested that autonomic responses occurred at sevoflurane anesthetic concentrations at which purposeful movements were absent.

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