MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization
- PMID: 22114354
- PMCID: PMC3258170
- DOI: 10.1091/mbc.E11-09-0774
MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization
Abstract
The inner membrane of mitochondria is especially protein rich and displays a unique morphology characterized by large invaginations, the mitochondrial cristae, and the inner boundary membrane, which is in proximity to the outer membrane. Mitochondrial inner membrane proteins appear to be not evenly distributed in the inner membrane, but instead organize into functionally distinct subcompartments. It is unknown how the organization of the inner membrane is achieved. We identified MINOS1/MIO10 (C1orf151/YCL057C-A), a conserved mitochondrial inner membrane protein. mio10-mutant yeast cells are affected in growth on nonfermentable carbon sources and exhibit altered mitochondrial morphology. At the ultrastructural level, mutant mitochondria display loss of inner membrane organization. Proteomic analyses reveal MINOS1/Mio10 as a novel constituent of Mitofilin/Fcj1 complexes in human and yeast mitochondria. Thus our analyses reveal new insight into the composition of the mitochondrial inner membrane organizing machinery.
Figures
Similar articles
-
Role of MINOS in mitochondrial membrane architecture: cristae morphology and outer membrane interactions differentially depend on mitofilin domains.J Mol Biol. 2012 Sep 14;422(2):183-91. doi: 10.1016/j.jmb.2012.05.004. Epub 2012 May 7. J Mol Biol. 2012. PMID: 22575891
-
Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology.Mol Biol Cell. 2013 Jun;24(12):1842-51. doi: 10.1091/mbc.E13-03-0125. Epub 2013 Apr 24. Mol Biol Cell. 2013. PMID: 23615445 Free PMC article.
-
The C-terminal domain of Fcj1 is required for formation of crista junctions and interacts with the TOB/SAM complex in mitochondria.Mol Biol Cell. 2012 Jun;23(11):2143-55. doi: 10.1091/mbc.E11-10-0831. Epub 2012 Apr 11. Mol Biol Cell. 2012. PMID: 22496419 Free PMC article.
-
Role of the mitochondrial contact site and cristae organizing system in membrane architecture and dynamics.Biochim Biophys Acta Mol Cell Res. 2017 Apr;1864(4):737-746. doi: 10.1016/j.bbamcr.2016.05.020. Epub 2016 Sep 7. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 27614134 Review.
-
Mitofilin complexes: conserved organizers of mitochondrial membrane architecture.Biol Chem. 2012 Nov;393(11):1247-61. doi: 10.1515/hsz-2012-0239. Biol Chem. 2012. PMID: 23109542 Review.
Cited by
-
Cellular Organelle-Related Transcriptomic Profile Abnormalities in Neuronopathic Types of Mucopolysaccharidosis: A Comparison with Other Neurodegenerative Diseases.Curr Issues Mol Biol. 2024 Mar 21;46(3):2678-2700. doi: 10.3390/cimb46030169. Curr Issues Mol Biol. 2024. PMID: 38534785 Free PMC article.
-
Drosophila MIC10b can polymerize into cristae-shaping filaments.Life Sci Alliance. 2024 Jan 22;7(4):e202302177. doi: 10.26508/lsa.202302177. Print 2024 Apr. Life Sci Alliance. 2024. PMID: 38253420 Free PMC article.
-
NLG1, encoding a mitochondrial membrane protein, controls leaf and grain development in rice.BMC Plant Biol. 2023 Sep 9;23(1):418. doi: 10.1186/s12870-023-04417-2. BMC Plant Biol. 2023. PMID: 37689677 Free PMC article.
-
RIP3 Translocation into Mitochondria Promotes Mitofilin Degradation to Increase Inflammation and Kidney Injury after Renal Ischemia-Reperfusion.Cells. 2022 Jun 11;11(12):1894. doi: 10.3390/cells11121894. Cells. 2022. PMID: 35741025 Free PMC article.
-
Protocol for engineering and validating a synthetic mitochondrial intermembrane bridge in mammalian cells.STAR Protoc. 2022 Jun 14;3(3):101454. doi: 10.1016/j.xpro.2022.101454. eCollection 2022 Sep 16. STAR Protoc. 2022. PMID: 35719722 Free PMC article.
References
-
- Arnold I, Bauer MF, Brunner M, Neupert W, Stuart RA. Yeast mitochondrial F1F0-ATPase: the novel subunit e is identical to Tim11. FEBS Lett. 1997;411:195–200. - PubMed
-
- Arnold I, Pfeiffer K, Neupert W, Stuart RA, Schägger H. ATP synthase of yeast mitochondriaIsolation of subunit j and disruption of the ATP18 gene. J Biol Chem. 1999;274:36–40. - PubMed
-
- Arselin G, Giraud MF, Dautant A, Vaillier J, Brèthes D, Coulary-Salin B, Schaeffer J, Velours J. The GxxxG motif of the transmembrane domain of subunit e is involved in the dimerization/oligomerization of the yeast ATP synthase complex in the mitochondrial membrane. Eur J Biochem. 2003;270:1875–1884. - PubMed
-
- Arselin G, Vaillier J, Salin B, Schaeffer J, Giraud MF, Dautant A, Brèthes D, Velours J. The modulation in subunits e and g amounts of yeast ATP synthase modifies mitochondrial cristae morphology. J Biol Chem. 2004;279:40392–40399. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases