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Randomized Controlled Trial
. 2012 Mar;33(2):410-6.
doi: 10.1016/j.cct.2011.11.011. Epub 2011 Nov 13.

Rationale and design of a trial on the effect of high dose statins on cardiovascular risk in adults after successful coarctation repair

Paul Luijendijk  1 , Berto J Bouma, Joris W J Vriend, Maarten Groenink, Hubert W Vliegen, Eric de Groot, Petronella G Pieper, Arie P J van Dijk, Gertjan T Sieswerda, Gerrit Veen, Aeilko H Zwinderman, Barbara J M Mulder
Affiliations
Randomized Controlled Trial

Rationale and design of a trial on the effect of high dose statins on cardiovascular risk in adults after successful coarctation repair

Paul Luijendijk et al. Contemp Clin Trials. 2012 Mar.

Abstract

Background: HMG-coA-reductase-inhibitors (statins) have been proven to reduce atherosclerosis progression as observed by carotid intima-media thickness in patients with known coronary heart disease, independent of lipid lowering. Cardiovascular complications are common in patients after successful coarctation repair. The effect of statins on cardiovascular risk in adults after successful coarctation repair has not yet been established.

Methods: We designed a multicentre, prospective, randomised, open label trial to evaluate the effect of the HMGcoA-reductase-inhibitor (Atorvastatin) on atherosclerotic progression in adult post-coarctectomy patients. The primary endpoint in this study is the carotid intima-media thickness as measured by Bmode ultrasonography of the carotid arteries.

Conclusion: This large prospective, randomised, open label trial will establish the effect of HMG-coA-reductase inhibitors (Atorvastatin) on cardiovascular risk in adult patients after successful coarctation repair.

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