Demographics and treatment trends in sinonasal mucosal melanoma
- PMID: 22024859
- DOI: 10.1002/lary.21925
Demographics and treatment trends in sinonasal mucosal melanoma
Abstract
Objectives/hypothesis: To evaluate the population characteristics of mucosal melanoma of the nasal cavity and paranasal sinuses and determine the impact of the new staging classification.
Study design: Analysis of a national database.
Methods: Patients were identified from the Surveillance, Epidemiology, and End Results tumor registry data with mucosal melanoma of the nasal cavity and paranasal sinuses between 2000 and 2007. Tumors were classified using the American Joint Committee on Cancer (AJCC) 6th edition site-specific staging as well as 7th edition staging for head and neck mucosal melanoma (HNMM). Incidence rates and descriptive statistics were calculated, and multivariate analysis was performed to examine the impact of demographic factors and staging on survival.
Results: A total of 304 patients were identified. The incidence rate was 0.05 per 100,000. Fifty-six percent were female, 92% were >50 years old, and more than 90% were Caucasian; 81.6% of patients were treated with surgery, and 38.5% of patients received postoperative radiation. Overall, the 5-year survival rate was 24.2%. Significant differences in survival were observed for surgery with radiation (P = .005) and surgery alone (P = .04) compared with radiation alone. TNM staging using the AJCC 6th and 7th edition classification schemes yielded similar survival curves. However, the new classification for HNMM allows for better delineation of stage IV disease, revealing slightly improved survival for stage IVA disease.
Conclusions: HNMM is a rare disease with a poor prognosis. Surgery remains the treatment of choice, with some role for adjuvant therapy. The new staging classification for HNMM appears to more efficiently stage this disease. Demographics and therapeutic findings are discussed.
Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.
Similar articles
-
[Clinical characteristics and prognosis of primary nasal mucosal melanoma--a report of 44 cases].Ai Zheng. 2006 Oct;25(10):1284-6. Ai Zheng. 2006. PMID: 17059777 Chinese.
-
Accuracy of the current TNM classification in predicting survival in patients with sinonasal mucosal melanoma.Laryngoscope. 2012 Aug;122(8):1734-8. doi: 10.1002/lary.23343. Epub 2012 May 1. Laryngoscope. 2012. PMID: 22549303
-
Malignant tumors of the nasal cavity and paranasal sinuses.Head Neck. 2002 Sep;24(9):821-9. doi: 10.1002/hed.10143. Head Neck. 2002. PMID: 12211046
-
Mucosal melanoma of the nasal cavity and paranasal sinuses.Eur Ann Otorhinolaryngol Head Neck Dis. 2014 Dec;131(6):365-369. doi: 10.1016/j.anorl.2013.11.004. Epub 2014 Jun 3. Eur Ann Otorhinolaryngol Head Neck Dis. 2014. PMID: 24906226 Review.
-
[Melanoma of the nasal fossae and sinuses, apropos of a series of 7 cases].Rev Laryngol Otol Rhinol (Bord). 1990;111(1):61-5. Rev Laryngol Otol Rhinol (Bord). 1990. PMID: 2130402 Review. French.
Cited by
-
Sinonasal mucosal melanoma in The Netherlands between 2001 and 2021: a clinical and epidemiological overview of 320 cases.Eur Arch Otorhinolaryngol. 2024 May 18. doi: 10.1007/s00405-024-08717-7. Online ahead of print. Eur Arch Otorhinolaryngol. 2024. PMID: 38761218
-
Multicenter Evaluation of Radiation and Immune Checkpoint Inhibitor Therapy in Mucosal Melanoma and Review of Recent Literature.Adv Radiat Oncol. 2023 Jul 9;9(1):101310. doi: 10.1016/j.adro.2023.101310. eCollection 2024 Jan. Adv Radiat Oncol. 2023. PMID: 38260223 Free PMC article.
-
Comparison of Prognostic Factors for Merkel Cell Carcinoma, Mucosal Melanoma and Cutaneous Malignant Melanoma: Insights into Their Etiologies.Curr Oncol. 2023 Mar 31;30(4):3974-3988. doi: 10.3390/curroncol30040301. Curr Oncol. 2023. PMID: 37185414 Free PMC article.
-
A nomogram for predicting overall survival of patients with sinonasal melanoma: A population-based study.Laryngoscope Investig Otolaryngol. 2022 Nov 22;7(6):1837-1848. doi: 10.1002/lio2.951. eCollection 2022 Dec. Laryngoscope Investig Otolaryngol. 2022. PMID: 36544933 Free PMC article.
-
Sinonasal Mucosal Melanoma: A Population-based Comparison of the EUROCARE and SEER Registries.Int Arch Otorhinolaryngol. 2022 Jan 27;26(3):e446-e452. doi: 10.1055/s-0041-1740099. eCollection 2022 Jul. Int Arch Otorhinolaryngol. 2022. PMID: 35846812 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical