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. 2011 Oct;22(7):703-10.
doi: 10.1097/FBP.0b013e32834affd2.

Neonatal exposure to the D1 agonist SKF38393 inhibits pair bonding in the adult prairie vole

Caroline M Hostetler  1 , Shanna L Harkey, Tarin B Krzywosinski, Brandon J Aragona, Karen L Bales
Affiliations

Neonatal exposure to the D1 agonist SKF38393 inhibits pair bonding in the adult prairie vole

Caroline M Hostetler et al. Behav Pharmacol. 2011 Oct.

Abstract

The monogamous prairie vole displays developmental sensitivity to early pharmacological manipulation in a number of species-typical social behaviors. The long-term consequences of altering the neonatal dopamine system are not well characterized. This study examined whether early manipulation of the dopamine system, a known mediator of adult prairie vole social behavior, during neonatal development would affect adult aggressive and attachment behaviors. Eight-day-old pups were given a single treatment with either 1 mg/kg of SKF38393 (D1 agonist), quinpirole (D2 agonist), SCH23390 (D1 antagonist), eticlopride (D2 antagonist), or saline vehicle. As adults, animals received tests for intrasexual aggression and partner preference. Activation of D1-like receptors in pups impaired partner preference formation, but had no effect on aggression. Other neonatal treatments had no effect on their behavior as adults. To determine whether D1 activation in pups induced changes in dopamine receptor expression, we performed autoradiography on striatal tissue from a second cohort of saline-treated and SKF38393-treated animals. Although sex differences were observed, we found no treatment differences in D1 or D2 receptor binding in any striatal subregion. This study shows that exposure to a single early pharmacological alteration of dopamine receptor activity may have long-term effects on the social behavior of prairie voles.

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Figures

Figure 1
Figure 1
Proportion of time spent in contact with the partner (light grey bars) or stranger (dark grey bars) relative to total contact time during Partner Preference Test, with males on the left and females on the right in each treatment pair. Sample sizes for each group are presented in parentheses. SKF treated subjects spent proportionately less time in contact with the partner when compared to saline controls. *Indicates significant effect of treatment on time spent with partner compared to saline controls, p<0.05.
Figure 2
Figure 2
Optical density of dopamine receptor autoradiography in the striatum by neonatal treatment (pooled by sex; a & c) and sex (pooled by treatment; b & d). There were no differences in any region between subjects treated with saline (dark bars) or SKF38393 (light bars). Males (white bars) had significantly higher receptor- and region-specific binding than females (hatched bars; * indicates p<0.05, # indicates p<0.10).
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