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. 2011 May-Jun;33(3):224-31.
doi: 10.1016/j.genhosppsych.2011.03.008. Epub 2011 Apr 27.

Depressive vulnerabilities predict depression status and trajectories of depression over 1 year in persons with acute coronary syndrome

Frank Doyle  1 , Hannah McGee, Mary Delaney, Nicola Motterlini, Ronán Conroy
Affiliations

Depressive vulnerabilities predict depression status and trajectories of depression over 1 year in persons with acute coronary syndrome

Frank Doyle et al. Gen Hosp Psychiatry. 2011 May-Jun.

Abstract

Objective: Depression is prevalent in patients hospitalized with acute coronary syndrome (ACS). We determined whether theoretical vulnerabilities for depression (interpersonal life events, reinforcing events, cognitive distortions, Type D personality) predicted depression, or depression trajectories, post-hospitalization.

Methods: We followed 375 ACS patients who completed depression scales during hospital admission and at least once during three follow-up intervals over 1 year (949 observations). Questionnaires assessing vulnerabilities were completed at baseline. Logistic regression for panel/longitudinal data predicted depression status during follow-up. Latent class analysis determined depression trajectories. Multinomial logistic regression modeled the relationship between vulnerabilities and trajectories.

Results: Vulnerabilities predicted depression status over time in univariate and multivariate analysis, even when controlling for baseline depression. Proportions in each depression trajectory category were as follows: persistent (15%), subthreshold (37%), never depressed (48%). Vulnerabilities independently predicted each of these trajectories, with effect sizes significantly highest for the persistent depression group.

Conclusions: Self-reported vulnerabilities - stressful life events, reduced reinforcing events, cognitive distortions, personality - measured during hospitalization can identify those at risk for depression post-ACS and especially those with persistent depressive episodes. Interventions should focus on these vulnerabilities.

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