Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles
- PMID: 21560073
- PMCID: PMC3142546
- DOI: 10.1007/s00018-011-0689-3
Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles
Abstract
Release of membrane vesicles, a process conserved in both prokaryotes and eukaryotes, represents an evolutionary link, and suggests essential functions of a dynamic extracellular vesicular compartment (including exosomes, microparticles or microvesicles and apoptotic bodies). Compelling evidence supports the significance of this compartment in a broad range of physiological and pathological processes. However, classification of membrane vesicles, protocols of their isolation and detection, molecular details of vesicular release, clearance and biological functions are still under intense investigation. Here, we give a comprehensive overview of extracellular vesicles. After discussing the technical pitfalls and potential artifacts of the rapidly emerging field, we compare results from meta-analyses of published proteomic studies on membrane vesicles. We also summarize clinical implications of membrane vesicles. Lessons from this compartment challenge current paradigms concerning the mechanisms of intercellular communication and immune regulation. Furthermore, its clinical implementation may open new perspectives in translational medicine both in diagnostics and therapy.
Figures
Similar articles
-
Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases.Pediatr Nephrol. 2019 Jan;34(1):11-30. doi: 10.1007/s00467-017-3816-z. Epub 2017 Nov 27. Pediatr Nephrol. 2019. PMID: 29181712 Free PMC article. Review.
-
[EXTRACELLULAR VESICLES: INTERCELLULAR INFORMATION FLOW AND MEDICAL APPLICATIONS].Tsitologiia. 2015;57(8):551-62. Tsitologiia. 2015. PMID: 26591566 Review. Russian.
-
Biology and proteomics of extracellular vesicles: harnessing their clinical potential.Expert Rev Proteomics. 2014 Jun;11(3):251-3. doi: 10.1586/14789450.2014.874290. Epub 2014 Jan 29. Expert Rev Proteomics. 2014. PMID: 24476411 Free PMC article.
-
Circulating extracellular vesicles in cancer diagnosis and monitoring: an appraisal of clinical potential.Mol Diagn Ther. 2013 Oct;17(5):265-71. doi: 10.1007/s40291-013-0042-7. Mol Diagn Ther. 2013. PMID: 23729224
-
Proteomics, transcriptomics and lipidomics of exosomes and ectosomes.Proteomics. 2013 May;13(10-11):1554-71. doi: 10.1002/pmic.201200329. Epub 2013 Mar 12. Proteomics. 2013. PMID: 23401200 Review.
Cited by
-
Salivary levels of azurocidin and soluble azurophilic granules in periodontal disease.J Med Life. 2024 Feb;17(2):205-209. doi: 10.25122/jml-2023-0286. J Med Life. 2024. PMID: 38813360 Free PMC article.
-
Effect of the 35 nm and 70 nm Size Exclusion Chromatography (SEC) Column and Plasma Storage Time on Separated Extracellular Vesicles.Curr Issues Mol Biol. 2024 May 6;46(5):4337-4357. doi: 10.3390/cimb46050264. Curr Issues Mol Biol. 2024. PMID: 38785532 Free PMC article.
-
Bioengineering extracellular vesicle cargo for optimal therapeutic efficiency.Mol Ther Methods Clin Dev. 2024 Apr 26;32(2):101259. doi: 10.1016/j.omtm.2024.101259. eCollection 2024 Jun 13. Mol Ther Methods Clin Dev. 2024. PMID: 38770107 Free PMC article. Review.
-
Cancer progression and tumor hypercoagulability: a platelet perspective.J Thromb Thrombolysis. 2024 May 17. doi: 10.1007/s11239-024-02993-0. Online ahead of print. J Thromb Thrombolysis. 2024. PMID: 38760535 Review.
-
Macrophage-derived ectosomal miR-350-3p promotes osteoarthritis progression through downregulating chondrocyte H3K36 methyltransferase NSD1.Cell Death Discov. 2024 May 8;10(1):223. doi: 10.1038/s41420-024-01986-5. Cell Death Discov. 2024. PMID: 38719811 Free PMC article.
References
-
- van der Pol E, Hoekstra AG, Sturk A, Otto C, van Leeuwen TG, Nieuwland R. Optical and non-optical methods for detection and characterization of microparticles and exosomes. J Thromb Haemost. 2010;8(12):2596–2607. - PubMed
-
- Islam A, Jones H, Hiroi T, Lam J, Zhang J, Moss J, Vaughan M, Levine SJ. cAMP-dependent protein kinase A (PKA) signaling induces TNFR1 exosome-like vesicle release via anchoring of PKA regulatory subunit RIIbeta to BIG2. J Biol Chem. 2008;283(37):25364–25371. doi: 10.1074/jbc.M804966200. - DOI - PMC - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources