Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats
- PMID: 21414089
- DOI: 10.1111/j.1440-1819.2010.02181.x
Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats
Abstract
Aim: Glycine, one of the non-essential amino acids, has been reported to be effective in reducing negative symptoms of schizophrenia. Recently, we found that glycine improves subjective sleep quality in humans. The aim of this study was to investigate the effects of oral glycine administration on endogenous 5-hydroxytryptamine (5-HT) and dopamine in the prefrontal cortex (PFC) of living rats.
Methods: Microdialysis probes were inserted stereotaxically into the rat prefrontal cortex. Cortical levels of 5-HT and dopamine were measured following oral administration of 1 or 2 g/kg glycine, 2 g/kg d-serine, or 2 g/kg L-serine.
Results: Both glycine and d-serine significantly increased extracellular 5-HT levels for 10 min, whereas dopamine levels remained unchanged. L-serine, in contrast, had no significant effects on 5-HT levels.
Conclusions: It is possible that the increase in 5-HT in response to glycine and d-serine was mediated by N-methyl-D-aspartate receptors. The transient increase in 5-HT in the PFC might be associated with the alleviation of negative symptoms in patients with schizophrenia and the amelioration of sleep quality in patients with insomnia.
© 2011 The Authors. Psychiatry and Clinical Neurosciences © 2011 Japanese Society of Psychiatry and Neurology.
Similar articles
-
Stimulation by neurotensin of dopamine and 5-hydroxytryptamine (5-HT) release from rat prefrontal cortex: possible role of NTR1 receptors in neuropsychiatric disorders.Neurochem Int. 2008 Dec;53(6-8):355-61. doi: 10.1016/j.neuint.2008.08.010. Epub 2008 Sep 12. Neurochem Int. 2008. PMID: 18835308
-
Effect of corticotropin releasing factor receptor 1 antagonist on extracellular norepinephrine, dopamine and serotonin in hippocampus and prefrontal cortex of rats in vivo.Neuropeptides. 2000 Jun-Aug;34(3-4):234-9. doi: 10.1054/npep.2000.0806. Neuropeptides. 2000. PMID: 11021986
-
Effect of zotepine on dopamine, serotonin and noradrenaline release in rat prefrontal cortex.Eur J Pharmacol. 2005 Dec 28;528(1-3):95-8. doi: 10.1016/j.ejphar.2005.10.045. Eur J Pharmacol. 2005. PMID: 16321379
-
New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.J Pharmacol Sci. 2012;118(2):145-8. doi: 10.1254/jphs.11r04fm. Epub 2012 Jan 27. J Pharmacol Sci. 2012. PMID: 22293292 Review.
-
[The effect of oral administration of glycine on metabolism].Nahrung. 1987;31(3):207-15. doi: 10.1002/food.19870310304. Nahrung. 1987. PMID: 3302716 Review. German.
Cited by
-
The endocannabinoidome mediator N-oleoylglycine is a novel protective agent against 1-methyl-4-phenyl-pyridinium-induced neurotoxicity.Front Aging Neurosci. 2022 Oct 14;14:926634. doi: 10.3389/fnagi.2022.926634. eCollection 2022. Front Aging Neurosci. 2022. PMID: 36313013 Free PMC article.
-
Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management.Mol Neurobiol. 2020 May;57(5):2144-2166. doi: 10.1007/s12035-020-01875-9. Epub 2020 Jan 20. Mol Neurobiol. 2020. PMID: 31960362 Free PMC article.
-
A Comparative Randomized Controlled Clinical Trial on the Effectiveness, Safety, and Tolerability of a Homeopathic Medicinal Product in Children with Sleep Disorders and Restlessness.Evid Based Complement Alternat Med. 2016;2016:9539030. doi: 10.1155/2016/9539030. Epub 2016 May 8. Evid Based Complement Alternat Med. 2016. PMID: 27242915 Free PMC article.
-
Orexin neurons receive glycinergic innervations.PLoS One. 2011;6(9):e25076. doi: 10.1371/journal.pone.0025076. Epub 2011 Sep 16. PLoS One. 2011. PMID: 21949857 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous