Herpes zoster incidence among insured persons in the United States, 1993-2006: evaluation of impact of varicella vaccination
- PMID: 21217180
- DOI: 10.1093/cid/ciq077
Herpes zoster incidence among insured persons in the United States, 1993-2006: evaluation of impact of varicella vaccination
Abstract
Background: herpes zoster (HZ) is caused by reactivation of latent varicella zoster virus and is often associated with substantial pain and disability. Baseline incidence of HZ prior to introduction of HZ vaccine is not well described, and it is unclear whether introduction of the varicella vaccination program in 1995 has altered the epidemiology of HZ. We examined trends in the incidence of HZ and impact of varicella vaccination on HZ trends using a large medical claims database.
Methods: medical claims data from the MarketScan databases were obtained for 1993-2006. We calculated HZ incidence using all persons with a first outpatient service associated with a 053.xx code (HZ ICD-9 code) as the numerator, and total MarketScan enrollment as the denominator; HZ incidence was stratified by age and sex. We used statewide varicella vaccination coverage in children aged 19-35 months to explore the impact of varicella vaccination on HZ incidence.
Results: HZ incidence increased for the entire study period and for all age groups, with greater rates of increase 1993-1996 (P < .001). HZ rates were higher for females than males throughout the study period (P < .001) and for all age groups (P < .001). HZ incidence did not vary by state varicella vaccination coverage.
Conclusions: HZ incidence has been increasing from 1993-2006. We found no evidence to attribute the increase to the varicella vaccine program.
Similar articles
-
Modelling the impact of a combined varicella and zoster vaccination programme on the epidemiology of varicella zoster virus in England.Vaccine. 2011 Mar 16;29(13):2411-20. doi: 10.1016/j.vaccine.2011.01.037. Epub 2011 Jan 28. Vaccine. 2011. PMID: 21277405
-
Modelling the impact of varicella vaccination on varicella and zoster.Epidemiol Infect. 2010 Apr;138(4):469-81. doi: 10.1017/S0950268809990768. Epub 2009 Oct 2. Epidemiol Infect. 2010. PMID: 19796447
-
The impact of the varicella vaccination program on herpes zoster epidemiology in the United States: a review.J Infect Dis. 2008 Mar 1;197 Suppl 2:S224-7. doi: 10.1086/522162. J Infect Dis. 2008. PMID: 18419401 Review.
-
The incidence and clinical characteristics of herpes zoster among children and adolescents after implementation of varicella vaccination.Pediatr Infect Dis J. 2009 Nov;28(11):954-9. doi: 10.1097/INF.0b013e3181a90b16. Pediatr Infect Dis J. 2009. PMID: 19536039
-
Varicella zoster vaccines.Dermatol Ther. 2009 Mar-Apr;22(2):143-9. doi: 10.1111/j.1529-8019.2009.01226.x. Dermatol Ther. 2009. PMID: 19335725 Review.
Cited by
-
Incidence of Herpes Zoster and Postherpetic Neuralgia and Herpes Zoster Vaccination Uptake in a US Administrative Claims Database.Open Forum Infect Dis. 2024 Apr 16;11(5):ofae211. doi: 10.1093/ofid/ofae211. eCollection 2024 May. Open Forum Infect Dis. 2024. PMID: 38737423 Free PMC article.
-
Herpes zoster in older adults: Impact on carbon footprint in the United States.Hum Vaccin Immunother. 2024 Dec 31;20(1):2335722. doi: 10.1080/21645515.2024.2335722. Epub 2024 May 3. Hum Vaccin Immunother. 2024. PMID: 38698759 Free PMC article.
-
Prior Herpes Simplex Virus Infection and the Risk of Herpes Zoster.J Infect Dis. 2024 Jan 12;229(1):64-72. doi: 10.1093/infdis/jiad259. J Infect Dis. 2024. PMID: 37410908 Free PMC article.
-
Safety and immunogenicity of a skin- and neuro-attenuated live vaccine for varicella: a randomized, double-blind, controlled, dose-escalation and age de-escalation phase 1 clinical trial.Lancet Reg Health West Pac. 2023 Feb 18;34:100707. doi: 10.1016/j.lanwpc.2023.100707. eCollection 2023 May. Lancet Reg Health West Pac. 2023. PMID: 37283962 Free PMC article.
-
Epidemiology of hospitalisations due to chickenpox and quality of life lost in community and hospital settings: protocol for a prospective cohort study across two countries.BMJ Open. 2023 Mar 29;13(3):e068611. doi: 10.1136/bmjopen-2022-068611. BMJ Open. 2023. PMID: 36990479 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical