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Clinical Trial
. 1990 Oct;52(4):726-30.
doi: 10.1093/ajcn/52.4.726.

Perdialytic parenteral nutrition with lipids and amino acids in malnourished hemodialysis patients

N Cano  1 , J Labastie-Coeyrehourq, P Lacombe, P Stroumza, J di Costanzo-Dufetel, J P Durbec, C Coudray-Lucas, L Cynober
Affiliations
Clinical Trial

Perdialytic parenteral nutrition with lipids and amino acids in malnourished hemodialysis patients

N Cano et al. Am J Clin Nutr. 1990 Oct.

Abstract

A 3-mo perdialytic parenteral nutrition (PDPN) regimen was tested in 26 malnourished adults receiving hemodialysis (HD). Subjects were randomly assigned to receive PDPN (n = 12) or not to receive it (n = 14). PDPN was intravenously infused three times a week during HD; each infusion was made up of 1.6 g fat/kg body wt, 0.08 g N/kg body wt, essential and nonessential amino acids, and glycyl-tyrosine. PDPN, together with a PDPN-induced increase in spontaneous eating, increased intakes from 30 +/- 8.4 kcal.kg body wt-1.d-1 (mean +/- SD) and 1 +/- 0.27 g protein.kg body wt-1.d-1 to 39 +/- 8.5 kcal.kg body wt-1.d-1 and 1.25 +/- 0.30 g protein.kg body wt-1.d-1. Compared with control subjects, PDPN patients were characterized by increases in body weight (P less than 0.01), arm-muscle circumference (P less than 0.02), serum transthyretin and albumin concentrations (P less than 0.05), interdialytic creatinine appearance (P less than 0.01), skin-test reactivity (P less than 0.02), plasma leucine (P less than 0.05) without modifications of other amino acids, and plasma apolipoprotein A-I (P less than 0.01) without significant changes in apolipoprotein B, cholesterol, triglyceride, and phospholipid concentrations. Thus, PDPN appeared to be effective and safe with respect to plasma lipids.

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