Mitochondrial fusion and fission in cell life and death
- PMID: 21102612
- DOI: 10.1038/nrm3013
Mitochondrial fusion and fission in cell life and death
Abstract
Mitochondria are dynamic organelles that constantly fuse and divide. These processes (collectively termed mitochondrial dynamics) are important for mitochondrial inheritance and for the maintenance of mitochondrial functions. The core components of the evolutionarily conserved fusion and fission machineries have now been identified, and mechanistic studies have revealed the first secrets of the complex processes that govern fusion and fission of a double membrane-bound organelle. Mitochondrial dynamics was recently recognized as an important constituent of cellular quality control. Defects have detrimental consequences on bioenergetic supply and contribute to the pathogenesis of neurodegenerative diseases. These findings open exciting new directions to explore mitochondrial biology.
Similar articles
-
The ever-growing complexity of the mitochondrial fission machinery.Cell Mol Life Sci. 2018 Feb;75(3):355-374. doi: 10.1007/s00018-017-2603-0. Epub 2017 Aug 5. Cell Mol Life Sci. 2018. PMID: 28779209 Free PMC article. Review.
-
Multi-patterned dynamics of mitochondrial fission and fusion in a living cell.PLoS One. 2012;7(5):e19879. doi: 10.1371/journal.pone.0019879. Epub 2012 May 23. PLoS One. 2012. PMID: 22649485 Free PMC article.
-
Importance of lipid metabolism for intracellular and mitochondrial membrane fusion/fission processes.Int J Biochem Cell Biol. 2009 Oct;41(10):1828-36. doi: 10.1016/j.biocel.2009.02.005. Epub 2009 Feb 20. Int J Biochem Cell Biol. 2009. PMID: 19703652 Review.
-
Regulation of mitochondrial fusion and division.Trends Cell Biol. 2007 Nov;17(11):563-9. doi: 10.1016/j.tcb.2007.08.006. Epub 2007 Oct 23. Trends Cell Biol. 2007. PMID: 17959383 Review.
-
In vitro assays for mitochondrial fusion and division.Methods Cell Biol. 2007;80:707-20. doi: 10.1016/S0091-679X(06)80032-4. Methods Cell Biol. 2007. PMID: 17445718 Review. No abstract available.
Cited by
-
Interplay Between Skeletal and Hematopoietic Cells in the Bone Marrow Microenvironment in Homeostasis and Aging.Curr Osteoporos Rep. 2024 May 23. doi: 10.1007/s11914-024-00874-2. Online ahead of print. Curr Osteoporos Rep. 2024. PMID: 38782850 Review.
-
Bacteria-organelle communication in physiology and disease.J Cell Biol. 2024 Jul 1;223(7):e202310134. doi: 10.1083/jcb.202310134. Epub 2024 May 15. J Cell Biol. 2024. PMID: 38748249 Free PMC article. Review.
-
SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation.Signal Transduct Target Ther. 2024 May 11;9(1):125. doi: 10.1038/s41392-024-01836-x. Signal Transduct Target Ther. 2024. PMID: 38734691 Free PMC article.
-
Circadian coordination: understanding interplay between circadian clock and mitochondria.Anim Cells Syst (Seoul). 2024 May 7;28(1):228-236. doi: 10.1080/19768354.2024.2347503. eCollection 2024. Anim Cells Syst (Seoul). 2024. PMID: 38721230 Free PMC article. Review.
-
Glucagon-like peptide-1 receptor agonist exendin 4 ameliorates diabetes-associated vascular calcification by regulating mitophagy through the AMPK signaling pathway.Mol Med. 2024 May 8;30(1):58. doi: 10.1186/s10020-024-00817-8. Mol Med. 2024. PMID: 38720283 Free PMC article.
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources