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. 2010:2010:4950-3.
doi: 10.1109/IEMBS.2010.5627243.

A closed-loop brain computer interface for real-time seizure detection and control

Sheng-Fu Liang  1 , Fu-Zen Shaw, Chung-Ping Young, Da-Wei Chang, Yi-Cheng Liao
Affiliations

A closed-loop brain computer interface for real-time seizure detection and control

Sheng-Fu Liang et al. Annu Int Conf IEEE Eng Med Biol Soc. 2010.

Abstract

The worldwide prevalence of epilepsy is approximately 1%, and 25% of epilepsy patients cannot be treated sufficiently by available therapies. Brain stimulation with closed-loop seizure control has recently been proposed as an innovative and effective alternative. In this paper, a portable closed-loop brain computer interface for seizure control was developed and shown with several aspects of advantages, including high seizure detection rate (92-99% during wake-sleep states), low false detection rate (1.2-2.5%), and small size. The seizure detection and electrical stimulation latency was not greater than 0.6 s after seizure onset. A wireless communication feature also provided flexibility for subjects freeing from the hassle of wires. Experimental data from freely moving rats supported the functional possibility of a real-time closed-loop seizure controller.

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