doi: 10.1021/ja1070224.
Substrate-induced covalent assembly of a chemzyme and crystallographic characterization of a chemzyme-substrate complex
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- PMID: 20863108
- DOI: 10.1021/ja1070224
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Substrate-induced covalent assembly of a chemzyme and crystallographic characterization of a chemzyme-substrate complex
J Am Chem Soc.
.
Abstract
A substrate induced covalent assembly of a highly organized chemzyme known to be effective in both catalytic asymmetric aziridination and aza Diels-Alder reactions is described and the information gained from which led to an efficient one-pot aziridination protocol. The crystal structures of two chemzyme-iminium complexes were elucidated by X-ray diffraction analysis that provides critical insights into the binding of the substrates with the chemzyme.
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