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Clinical Trial
. 2011 Jan;95(1):50-60, 60.e1-15.
doi: 10.1016/j.fertnstert.2010.04.063. Epub 2010 Jul 8.

A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature

Patricia Díaz-Gimeno  1 , José A Horcajadas, José A Martínez-Conejero, Francisco J Esteban, Pilar Alamá, Antonio Pellicer, Carlos Simón
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Free article
Clinical Trial

A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature

Patricia Díaz-Gimeno et al. Fertil Steril. 2011 Jan.
Free article

Abstract

Objective: To create a genomic tool composed of a customized microarray and a bioinformatic predictor for endometrial dating and to detect pathologies of endometrial origin. To define the transcriptomic signature of human endometrial receptivity.

Design: Two cohorts of endometrial samples along the menstrual cycle were used: one to select the genes to be included in the customized microarray (endometrial receptivity array [ERA]), and the other to be analyzed by ERA to train the predictor for endometrial dating and to define the transcriptomic signature. A third cohort including pathological endometrial samples was used to train the predictor for pathological classification.

Setting: Healthy oocyte donors and patients.

Patient(s): Healthy fertile women (88) and women with implantation failure (5) or hydrosalpinx (2).

Intervention(s): Human endometrial biopsies.

Main outcome measure(s): The gene expression of endometrial biopsies.

Result(s): The ERA included 238 selected genes. The transcriptomic signature was defined by 134 genes. The predictor showed a specificity of 0.8857 and sensitivity of 0.99758 for endometrial dating, and a specificity of 0.1571 and a sensitivity of 0.995 for the pathological classification.

Conclusion(s): This diagnostic tool can be used clinically in reproductive medicine and gynecology. The transcriptomic signature is a potential endometrial receptivity biomarkers cluster.

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