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Randomized Controlled Trial
. 2010 Mar;202(3):239.e1-239.e10.
doi: 10.1016/j.ajog.2010.01.050.

An international trial of antioxidants in the prevention of preeclampsia (INTAPP)

Hairong Xu  1 , Ricardo Perez-Cuevas, Xu Xiong, Hortensia Reyes, Chantal Roy, Pierre Julien, Graeme Smith, Peter von Dadelszen, Line Leduc, François Audibert, Jean-Marie Moutquin, Bruno Piedboeuf, Bryna Shatenstein, Socorro Parra-Cabrera, Pierre Choquette, Stephanie Winsor, Stephen Wood, Alice Benjamin, Mark Walker, Michael Helewa, Johanne Dubé, Georges Tawagi, Gareth Seaward, Arne Ohlsson, Laura A Magee, Femi Olatunbosun, Robert Gratton, Roberta Shear, Nestor Demianczuk, Jean-Paul Collet, Shuqin Wei, William D Fraser; INTAPP study group
Affiliations
Randomized Controlled Trial

An international trial of antioxidants in the prevention of preeclampsia (INTAPP)

Hairong Xu et al. Am J Obstet Gynecol. 2010 Mar.

Abstract

Objective: We sought to investigate whether prenatal vitamin C and E supplementation reduces the incidence of gestational hypertension (GH) and its adverse conditions among high- and low-risk women.

Study design: In a multicenter randomized controlled trial, women were stratified by the risk status and assigned to daily treatment (1 g vitamin C and 400 IU vitamin E) or placebo. The primary outcome was GH and its adverse conditions.

Results: Of the 2647 women randomized, 2363 were included in the analysis. There was no difference in the risk of GH and its adverse conditions between groups (relative risk, 0.99; 95% confidence interval, 0.78-1.26). However, vitamins C and E increased the risk of fetal loss or perinatal death (nonprespecified) as well as preterm prelabor rupture of membranes.

Conclusion: Vitamin C and E supplementation did not reduce the rate of preeclampsia or GH, but increased the risk of fetal loss or perinatal death and preterm prelabor rupture of membranes.

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