Genomics studies of immune-mediated diseases using the BN-LEW rat model
- PMID: 20013247
- DOI: 10.1007/978-1-60327-389-3_26
Genomics studies of immune-mediated diseases using the BN-LEW rat model
Abstract
LEW and BN rats, that behave in opposite ways for their susceptibility to various immune-mediated diseases, provide a powerful model to investigate the molecular and genetic bases of immune system physiology and dysregulation. Using this model, we addressed the question of the genetic control of central nervous system autoimmunity, of xenobiotic-induced allergic diseases, and of T cell subsets that differ by their cytokine profiles. By linkage analysis and genetic dissection, using a panel of congenic rats, we identified a 120 Kb region on chromosome 9 that controls all these phenotypes, indicating that this region contains a gene or set of genes that plays an important role in the immune system homeostasis and susceptibility to immune mediated diseases. In this review, we will describe these rat genomics studies and will discuss the cellular and genetic factors that may be involved in the differences between these rat strains.
Similar articles
-
Cellular and genetic factors involved in the difference between Brown Norway and Lewis rats to develop respectively type-2 and type-1 immune-mediated diseases.Immunol Rev. 2001 Dec;184:145-60. doi: 10.1034/j.1600-065x.2001.1840114.x. Immunol Rev. 2001. PMID: 12086309 Review.
-
SHR.BN-congenic strains for genetic analysis of multifactorially determined traits.Folia Biol (Praha). 2000;46(1):25-9. Folia Biol (Praha). 2000. PMID: 10730879 Review.
-
The LEW.BN(2R) strain: a recombinant in the rat MHC.J Immunol. 1980 May;124(5):2247-53. J Immunol. 1980. PMID: 6154096
-
Mercury-induced renal autoimmunity in BN-->LEW.1N chimeric rats.Cell Immunol. 1994 Apr 15;155(1):77-94. doi: 10.1006/cimm.1994.1103. Cell Immunol. 1994. PMID: 8168152
-
Genetic control of the development of experimental allergic encephalomyelitis in rats. Separation of MHC and non-MHC gene effects.J Immunol. 1988 Sep 1;141(5):1489-94. J Immunol. 1988. PMID: 2457618
Cited by
-
Immune suppressive drugs negatively regulate the CD8+T cells function by acetyltransferase p300 induced canonical and non-canonical autophagy.Heliyon. 2024 Jun 29;10(13):e33755. doi: 10.1016/j.heliyon.2024.e33755. eCollection 2024 Jul 15. Heliyon. 2024. PMID: 39071589 Free PMC article.
-
Advances in Genome Editing and Application to the Generation of Genetically Modified Rat Models.Front Genet. 2021 Apr 20;12:615491. doi: 10.3389/fgene.2021.615491. eCollection 2021. Front Genet. 2021. PMID: 33959146 Free PMC article. Review.
-
Maternal plasma proteomics in a rat model of pregnancy complications reveals immune and pro-coagulant gene pathway activation.Am J Reprod Immunol. 2020 Feb;83(2):e13205. doi: 10.1111/aji.13205. Epub 2019 Nov 23. Am J Reprod Immunol. 2020. PMID: 31677200 Free PMC article.
-
[Regulatory effect of Vav1 on T cells and its relation to clinical diseases].Zhejiang Da Xue Xue Bao Yi Xue Ban. 2018 Jan 25;47(1):75-81. doi: 10.3785/j.issn.1008-9292.2018.02.11. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2018. PMID: 30146815 Free PMC article. Review. Chinese.
-
A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.PLoS Genet. 2016 Jul 20;12(7):e1006185. doi: 10.1371/journal.pgen.1006185. eCollection 2016 Jul. PLoS Genet. 2016. PMID: 27438086 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
