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Randomized Controlled Trial
. 2010 Oct;94(5):1812-6.
doi: 10.1016/j.fertnstert.2009.11.001. Epub 2009 Dec 11.

Lifestyle management improves quality of life and depression in overweight and obese women with polycystic ovary syndrome

Rebecca L Thomson  1 , Jonathan D Buckley, Siew S Lim, Manny Noakes, Peter M Clifton, Robert J Norman, Grant D Brinkworth
Affiliations
Free article
Randomized Controlled Trial

Lifestyle management improves quality of life and depression in overweight and obese women with polycystic ovary syndrome

Rebecca L Thomson et al. Fertil Steril. 2010 Oct.
Free article

Abstract

Objective: To assess the impact of adding exercise to dietary restriction on depressive symptoms and health-related quality of life (HRQOL) in women with polycystic ovary syndrome (PCOS).

Design: Analysis of depression and quality of life outcomes from a randomized, controlled prospective clinical intervention that evaluated the effects on a range of health outcomes in women with PCOS.

Setting: Clinical research unit.

Patient(s): One hundred four overweight/obese PCOS women (aged 29.3 ± 0.7 years; body mass index [BMI] 36.1 ± 0.5 kg/m(2)).

Intervention(s): Randomized to one of three 20-week lifestyle programs: diet only, diet and aerobic exercise, or diet and combined aerobic-resistance exercise.

Main outcome measure(s): Depression and PCOS-specific HRQOL.

Result(s): Forty-nine women completed the intervention (diet only = 14, diet and aerobic exercise = 15, diet and combined aerobic-resistance exercise = 20). By week 20 all groups achieved weight loss and had improvements in depression and PCOS-specific HRQOL scores, except for body hair domain score. There was no difference between treatments for all outcomes.

Conclusion(s): This study demonstrated that dietary restriction alone and combined with exercise had similar benefits for improving depression and HRQOL scores in overweight and obese women with PCOS.

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