Male-female differences in the effects of cannabinoids on sexual behavior and gonadal hormone function
- PMID: 19733173
- DOI: 10.1016/j.yhbeh.2009.08.009
Male-female differences in the effects of cannabinoids on sexual behavior and gonadal hormone function
Abstract
The putative role of the endocannabinoid system and the effects of cannabis use in male and female sexual functioning are summarized. The influence of cannabis intake on sexual behavior and arousability appear to be dose-dependent in both men and women, although women are far more consistent in reporting facilitatory effects. Furthermore, evidence from nonhuman species indicate somewhat more beneficial than debilitating effects of cannabinoids on female sexual proceptivity and receptivity while suggesting predominantly detrimental effects on male sexual motivation and erectile functioning. Data from human and nonhuman species converge on the ephemeral nature of THC-induced testosterone decline. However, it is clear that cannabinoid-induced inhibition of male sexual behavior is independent of concurrent declines in testosterone levels. Investigations also reveal a suppression of gonadotropin release by cannabinoids across various species. Historical milestones and promising future directions in the area of cannabinoid and sexuality research are also outlined in this review.
Copyright 2009 Elsevier Inc. All rights reserved.
Similar articles
-
Cannabinoid-hormone interactions in the regulation of motivational processes.Horm Behav. 2010 Jun;58(1):100-10. doi: 10.1016/j.yhbeh.2009.10.005. Epub 2009 Oct 9. Horm Behav. 2010. PMID: 19819241 Review.
-
Sex differences and gonadal hormone influences in drug addiction and sexual behavior: progress and possibilities.Horm Behav. 2010 Jun;58(1):2-7. doi: 10.1016/j.yhbeh.2010.03.004. Epub 2010 Mar 6. Horm Behav. 2010. PMID: 20211183 No abstract available.
-
Has dopamine a physiological role in the control of sexual behavior? A critical review of the evidence.Prog Neurobiol. 2004 Jun;73(3):179-226. doi: 10.1016/j.pneurobio.2004.05.001. Prog Neurobiol. 2004. PMID: 15236835 Review.
-
The endocrinology of sexual arousal.J Endocrinol. 2005 Sep;186(3):411-27. doi: 10.1677/joe.1.06233. J Endocrinol. 2005. PMID: 16135662 Review.
-
Mixing pleasures: review of the effects of drugs on sex behavior in humans and animal models.Horm Behav. 2010 Jun;58(1):149-62. doi: 10.1016/j.yhbeh.2009.11.009. Epub 2009 Dec 31. Horm Behav. 2010. PMID: 20004662 Review.
Cited by
-
Assessment of the effect of cannabis use before partnered sex on women with and without orgasm difficulty.Sex Med. 2024 May 6;12(2):qfae023. doi: 10.1093/sexmed/qfae023. eCollection 2024 Apr. Sex Med. 2024. PMID: 38711949 Free PMC article.
-
Could cannabinoids provide a new hope for ovarian cancer patients?Pharmacol Res Perspect. 2023 Aug;11(4):e01122. doi: 10.1002/prp2.1122. Pharmacol Res Perspect. 2023. PMID: 37526235 Free PMC article. Review.
-
Association of cannabis use with depression among cancer patients.Prev Med Rep. 2023 Jun 29;35:102304. doi: 10.1016/j.pmedr.2023.102304. eCollection 2023 Oct. Prev Med Rep. 2023. PMID: 37455758 Free PMC article.
-
Sex- and Gender-Specific Drug Abuse Dynamics: The Need for Tailored Therapeutic Approaches.J Pers Med. 2023 Jun 8;13(6):965. doi: 10.3390/jpm13060965. J Pers Med. 2023. PMID: 37373954 Free PMC article.
-
Endocannabinoid System in the Neuroendocrine Response to Lipopolysaccharide-induced Immune Challenge.J Endocr Soc. 2022 Aug 11;6(10):bvac120. doi: 10.1210/jendso/bvac120. eCollection 2022 Oct 1. J Endocr Soc. 2022. PMID: 36042978 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources