Treatment with peginterferon plus ribavirin vs. interferon plus ribavirin for 48 weeks in Chinese patients with chronic hepatitis C
- PMID: 19691617
- DOI: 10.1111/j.1742-1241.2009.02082.x
Treatment with peginterferon plus ribavirin vs. interferon plus ribavirin for 48 weeks in Chinese patients with chronic hepatitis C
Abstract
Introduction: Virological responses to interferon (IFN) treatment for chronic hepatitis C (CHC) have been found to be correlated with racial differences. Furthermore, higher sustained virological response (SVR) rates were obtained in many randomised clinical trials (RCT) in Caucasian patients with CHC after treating with peg-IFN than those with IFN. However, it is not clear whether this conclusion can be adapted to patients of Chinese descent.
Methods: A search of MEDLINE and China National Knowledge Infrastructure between 1966 and 2008 was performed. Trials comparing the use of peg-IFN plus ribavirin vs. IFN plus ribavirin in treating Chinese patients with CHC were assessed.
Results: Of the 94 studies screened, seven RCTs including 398 patients (peg-IFN therapy 232, IFN therapy 166) were analysed. The SVRs obtained in patients treated with peg-IFN plus ribavirin were significantly higher than in patients treated with IFN plus ribavirin [70% vs. 35%, relative risk, 1.76; 95% confidence interval: 1.21-2.56; p (0.01)]. Withdrawal rates were similar between patients treated with peg-IFN plus ribavirin and IFN plus ribavirin.
Conclusion: Chinese patients with CHC also have a greater likelihood of achieving an SVR with peg-IFN plus ribavirin.
Similar articles
-
Pegylated interferon-α2a and ribavirin versus pegylated interferon-α2b and ribavirin in chronic hepatitis C : a meta-analysis.Drugs. 2013 Mar;73(3):263-77. doi: 10.1007/s40265-013-0027-1. Drugs. 2013. PMID: 23436591 Review.
-
Pegylated alpha-interferon-2a plus ribavirin compared with pegylated alpha-interferon-2b plus ribavirin for initial treatment of chronic hepatitis C virus: prospective, non-randomized study.J Gastroenterol Hepatol. 2008 Jun;23(6):861-6. doi: 10.1111/j.1440-1746.2008.05397.x. Epub 2008 Apr 19. J Gastroenterol Hepatol. 2008. PMID: 18422960 Clinical Trial.
-
Virological response in patients with hepatitis C virus genotype 1b and a high viral load: impact of peginterferon-alpha-2a plus ribavirin dose reductions and host-related factors.Clin Drug Investig. 2008;28(1):9-16. doi: 10.2165/00044011-200828010-00002. Clin Drug Investig. 2008. PMID: 18081356
-
Predictive value of early virological response to treatment with different interferon-based regimens plus ribavirin in patients with chronic hepatitis C.New Microbiol. 2005 Jan;28(1):13-21. New Microbiol. 2005. PMID: 15782622 Clinical Trial.
-
Pegylated interferon alpha-2a and -2b in combination with ribavirin in the treatment of chronic hepatitis C: a systematic review and economic evaluation.Health Technol Assess. 2004 Oct;8(39):iii-iv, 1-125. doi: 10.3310/hta8390. Health Technol Assess. 2004. PMID: 15461877 Review.
Cited by
-
Cost Effectiveness of Daclatasvir Plus Asunaprevir Therapy for Chinese Patients with Chronic Hepatitis C Virus Genotype 1b.Clin Drug Investig. 2018 May;38(5):427-437. doi: 10.1007/s40261-018-0621-9. Clin Drug Investig. 2018. PMID: 29417464
-
Estimating cost-effectiveness associated with all-oral regimen for chronic hepatitis C in China.PLoS One. 2017 Apr 5;12(4):e0175189. doi: 10.1371/journal.pone.0175189. eCollection 2017. PLoS One. 2017. PMID: 28380022 Free PMC article.
-
Features of hepatitis C virus infection, current therapies and ongoing clinical trials in ten Asian Pacific countries.Hepatol Int. 2015 Oct;9(4):486-507. doi: 10.1007/s12072-015-9630-4. Epub 2015 May 5. Hepatol Int. 2015. PMID: 25941137 Review.
-
Peginterferon plus Chinese herbal therapy is associated with a higher virological response than only peginterferon therapy in chronic hepatitis C.Eur J Clin Microbiol Infect Dis. 2014 Mar;33(3):433-8. doi: 10.1007/s10096-013-1973-y. Eur J Clin Microbiol Infect Dis. 2014. PMID: 24022094
-
A new era in the treatment of chronic hepatitis C infection.Indian J Gastroenterol. 2013 Mar;32(2):71-9. doi: 10.1007/s12664-012-0254-5. Epub 2012 Sep 28. Indian J Gastroenterol. 2013. PMID: 23054947 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical