Modulation of calcium signalling by mitochondria
- PMID: 19344663
- DOI: 10.1016/j.bbabio.2009.01.007
Modulation of calcium signalling by mitochondria
Abstract
In this review we will attempt to summarise the complex and sometimes contradictory effects that mitochondria have on different forms of calcium signalling. Mitochondria can influence Ca(2+) signalling indirectly by changing the concentration of ATP, NAD(P)H, pyruvate and reactive oxygen species - which in turn modulate components of the Ca(2+) signalling machinery i.e. buffering, release from internal stores, influx from the extracellular solution, uptake into cellular organelles and extrusion by plasma membrane Ca(2+) pumps. Mitochondria can directly influence the calcium concentration in the cytosol of the cell by importing Ca(2+) via the mitochondrial Ca(2+) uniporter or transporting Ca(2+) from the interior of the organelle into the cytosol by means of Na+/Ca(2+) or H+/Ca(2+) exchangers. Considerable progress in understanding the relationship between Ca(2+) signalling cascades and mitochondrial physiology has been accumulated over the last few years due to the development of more advanced optical techniques and electrophysiological approaches.
Similar articles
-
Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate-evoked calcium signaling.J Biol Chem. 2019 Jan 18;294(3):737-758. doi: 10.1074/jbc.RA118.005913. Epub 2018 Nov 29. J Biol Chem. 2019. PMID: 30498088 Free PMC article.
-
[Endoplasmic-mitochondrial Ca(2+)-functional unit: dependence of respiration of secretory cells on activity of ryanodine- and IP3 - sensitive Ca(2+)-channels].Ukr Biokhim Zh (1999). 2012 Sep-Oct;84(5):76-88. Ukr Biokhim Zh (1999). 2012. PMID: 23342638 Ukrainian.
-
Calcium signalling in astroglia.Mol Cell Endocrinol. 2012 Apr 28;353(1-2):45-56. doi: 10.1016/j.mce.2011.08.039. Epub 2011 Sep 10. Mol Cell Endocrinol. 2012. PMID: 21945602 Review.
-
SR/ER-mitochondrial local communication: calcium and ROS.Biochim Biophys Acta. 2009 Nov;1787(11):1352-62. doi: 10.1016/j.bbabio.2009.06.004. Epub 2009 Jun 13. Biochim Biophys Acta. 2009. PMID: 19527680 Free PMC article. Review.
-
H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus.Pflugers Arch. 2009 Sep;458(5):937-52. doi: 10.1007/s00424-009-0672-0. Epub 2009 May 10. Pflugers Arch. 2009. PMID: 19430810 Free PMC article.
Cited by
-
Targeting MCL-1 protein to treat cancer: opportunities and challenges.Front Oncol. 2023 Jul 31;13:1226289. doi: 10.3389/fonc.2023.1226289. eCollection 2023. Front Oncol. 2023. PMID: 37601693 Free PMC article. Review.
-
Oxidative Stress: A Suitable Therapeutic Target for Optic Nerve Diseases?Antioxidants (Basel). 2023 Jul 20;12(7):1465. doi: 10.3390/antiox12071465. Antioxidants (Basel). 2023. PMID: 37508003 Free PMC article. Review.
-
Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy.Front Endocrinol (Lausanne). 2022 Jun 15;13:907757. doi: 10.3389/fendo.2022.907757. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35784531 Free PMC article. Review.
-
A New Transgenic Mouse Line for Imaging Mitochondrial Calcium Signals.Function (Oxf). 2021 Feb 25;2(3):zqab012. doi: 10.1093/function/zqab012. eCollection 2021. Function (Oxf). 2021. PMID: 35330679 Free PMC article.
-
Effects of Mild Excitotoxic Stimulus on Mitochondria Ca2+ Handling in Hippocampal Cultures of a Mouse Model of Alzheimer's Disease.Cells. 2021 Aug 10;10(8):2046. doi: 10.3390/cells10082046. Cells. 2021. PMID: 34440815 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Miscellaneous
