Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2009 Mar 27;104(6):717-9.
doi: 10.1161/CIRCRESAHA.109.195495.

Innate short-circuiting of mitochondrial metabolism in cardiac hypertrophy: identification of novel consequences of enhanced anaplerosis

Michael N Sack
Editorial

Innate short-circuiting of mitochondrial metabolism in cardiac hypertrophy: identification of novel consequences of enhanced anaplerosis

Michael N Sack. Circ Res. .
No abstract available

PubMed Disclaimer

Figures

Figure
Figure
Schematic of pathway perturbations by increased malic enzyme–driven anaplerosis. The arrow line thickness and text size reflect the hypothetical relative reaction rates and the putative deficits in reducing equivalent generation and reduction in NADPH-dependent pathways associated with malic enzyme carboxylation of pyruvate in cardiac hypertrophy.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Frohlich ED, Apstein C, Chobanian AV, Devereux RB, Dustan HP, Dzau V, Fauad-Tarazi F, Horan MJ, Marcus M, Massie B, Pfeffer MA, Re RN, Roccella EJ, Savage D, Shub C. The heart in hypertension. N Engl J Med. 1992;327:998–1008. - PubMed
    1. Sack MN, Rader TA, Park S, Bastin J, McCune SA, Kelly DP. Fatty acid enzyme encoding gene expression is downregulated in the failing heart. Circulation. 1996;94:2837–2842. - PubMed
    1. Sack MN, Disch DL, Rockman HA, Kelly DP. A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sci U S A. 1997;94:6438–6443. - PMC - PubMed
    1. Barger PM, Brandt JM, Leone TC, Weinheimer CJ, Kelly DP. Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth. J Clin Invest. 2000;105:1723–1730. - PMC - PubMed
    1. Huss JM, Kelly DP. Nuclear receptor signaling and cardiac energetics. Circ Res. 2004;95:568–578. - PubMed