The intracellular renin-angiotensin system in the heart
- PMID: 19278599
- DOI: 10.1007/s11906-009-0020-y
The intracellular renin-angiotensin system in the heart
Abstract
Recently, several novel aspects of the renin-angiotensin system (RAS) were described, which potentially may change the therapeutic strategy to treat cardiovascular disease, in addition to enhancing understanding of this system's mechanism of action. Most notably, identification of a functional intracellular RAS may address several unanswered questions regarding a direct role of angiotensin (Ang) II in cardiac remodeling and incomplete efficacy of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers or superiority of a renin inhibitor in cardiovascular disorders. We describe the physiology of the intracellular RAS, potential pathologic roles of intracellular Ang II, and the relevance of the intracellular system in view of recent clinical trials involving various RAS inhibitors.
Similar articles
-
Impact of angiotensin II on the kidney: does an angiotensin II receptor blocker make sense?Am J Kidney Dis. 2000 Sep;36(3 Suppl 1):S18-23. doi: 10.1053/ajkd.2000.9682. Am J Kidney Dis. 2000. PMID: 10986155 Review.
-
Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production.Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1675-84. doi: 10.1152/ajpheart.91493.2007. Epub 2008 Feb 22. Am J Physiol Heart Circ Physiol. 2008. PMID: 18296558
-
AHU377+Valsartan (LCZ696) Modulates Renin-Angiotensin System (RAS) in the Cardiac of Female Spontaneously Hypertensive Rats Compared With Valsartan.J Cardiovasc Pharmacol Ther. 2019 Sep;24(5):450-459. doi: 10.1177/1074248419838503. Epub 2019 Apr 25. J Cardiovasc Pharmacol Ther. 2019. PMID: 31023080
-
The renin-angiotensin system: importance in physiology and pathology.J Cardiovasc Pharmacol. 1990;15 Suppl 3:S1-5. J Cardiovasc Pharmacol. 1990. PMID: 1691411 Review.
-
Cardiac remodelling and RAS inhibition.Ther Adv Cardiovasc Dis. 2016 Jun;10(3):162-71. doi: 10.1177/1753944716642677. Epub 2016 Apr 21. Ther Adv Cardiovasc Dis. 2016. PMID: 27105891 Free PMC article. Review.
Cited by
-
Cardioprotective Mechanisms against Reperfusion Injury in Acute Myocardial Infarction: Targeting Angiotensin II Receptors.Biomedicines. 2022 Dec 22;11(1):17. doi: 10.3390/biomedicines11010017. Biomedicines. 2022. PMID: 36672525 Free PMC article. Review.
-
Possible Benefits of Zinc supplement in CVD and COVID-19 Comorbidity.J Infect Public Health. 2021 Nov;14(11):1686-1692. doi: 10.1016/j.jiph.2021.09.022. Epub 2021 Oct 4. J Infect Public Health. 2021. PMID: 34649043 Free PMC article. Review.
-
The Impact of microRNAs in Renin-Angiotensin-System-Induced Cardiac Remodelling.Int J Mol Sci. 2021 Apr 30;22(9):4762. doi: 10.3390/ijms22094762. Int J Mol Sci. 2021. PMID: 33946230 Free PMC article. Review.
-
Possible Susceptibility Genes for Intervention against Chemotherapy-Induced Cardiotoxicity.Oxid Med Cell Longev. 2020 Oct 13;2020:4894625. doi: 10.1155/2020/4894625. eCollection 2020. Oxid Med Cell Longev. 2020. PMID: 33110473 Free PMC article. Review.
-
Angiotensin Receptors Heterodimerization and Trafficking: How Much Do They Influence Their Biological Function?Front Pharmacol. 2020 Aug 3;11:1179. doi: 10.3389/fphar.2020.01179. eCollection 2020. Front Pharmacol. 2020. PMID: 32848782 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Miscellaneous