Basic and clinical aspects of gastrointestinal pain
- PMID: 19155134
- DOI: 10.1016/j.pain.2008.12.011
Basic and clinical aspects of gastrointestinal pain
Abstract
The gastrointestinal (GI) tract is a system of organs within multicellular animals which facilitates the ingestion, digestion, and absorption of food with subsequent defecation of waste. A complex arrangement of nerves and ancillary cells contributes to the sensorimotor apparatus required to subserve such essential functions that are with the exception of the extreme upper and lower ends of the GI tract normally subconscious. However, it also has the potential to provide conscious awareness of injury. Although this function can be protective, when dysregulated, particularly on a chronic basis, the same system can lead to considerable morbidity. The anatomical and molecular basis of gastrointestinal nociception, conditions associated with chronic unexplained visceral pain, and developments in treatment are presented in this review.
Similar articles
-
Involvement of metabotropic glutamate 5 receptor in visceral pain.Pain. 2008 Jul 15;137(2):295-305. doi: 10.1016/j.pain.2007.09.008. Epub 2007 Oct 15. Pain. 2008. PMID: 17937975
-
Visceral nociception.Curr Rev Pain. 2000;4(6):478-87. doi: 10.1007/s11916-000-0072-9. Curr Rev Pain. 2000. PMID: 11060594 Free PMC article. Review.
-
Visceral pain.Curr Rev Pain. 2000;4(6):499-506. doi: 10.1007/s11916-000-0074-7. Curr Rev Pain. 2000. PMID: 11060596 Review.
-
Biological basis of child health 8: development of the gastrointestinal system and associated childhood conditions.Nurs Child Young People. 2021 May 6;33(3):32-41. doi: 10.7748/ncyp.2020.e1101. Epub 2020 Nov 2. Nurs Child Young People. 2021. PMID: 33135874
-
Visceral Pain.Annu Rev Physiol. 2019 Feb 10;81:261-284. doi: 10.1146/annurev-physiol-020518-114525. Epub 2018 Oct 31. Annu Rev Physiol. 2019. PMID: 30379615 Review.
Cited by
-
Neuropancreatology: The Nervous System and Pain Management in Pancreatic Diseases.Life (Basel). 2024 Feb 23;14(3):299. doi: 10.3390/life14030299. Life (Basel). 2024. PMID: 38541624 Free PMC article. Review.
-
Chronic Visceral Pain: New Peripheral Mechanistic Insights and Resulting Treatments.Gastroenterology. 2024 Jun;166(6):976-994. doi: 10.1053/j.gastro.2024.01.045. Epub 2024 Feb 5. Gastroenterology. 2024. PMID: 38325759 Review.
-
Transcutaneous auricular vagus nerve stimulation in the treatment of disorders of consciousness: mechanisms and applications.Front Neurosci. 2023 Oct 18;17:1286267. doi: 10.3389/fnins.2023.1286267. eCollection 2023. Front Neurosci. 2023. PMID: 37920298 Free PMC article. Review.
-
Genetic and Pharmacological Blockade of Sigma-1 Receptors Attenuates Inflammation-Associated Hypersensitivity during Acute Colitis in CD1 Mice.Biomedicines. 2023 Oct 12;11(10):2758. doi: 10.3390/biomedicines11102758. Biomedicines. 2023. PMID: 37893131 Free PMC article.
-
Mendelian randomization study of gastroesophageal reflux disease and major depression.PLoS One. 2023 Sep 28;18(9):e0291086. doi: 10.1371/journal.pone.0291086. eCollection 2023. PLoS One. 2023. PMID: 37768900 Free PMC article.
References
-
- Ait-Belgnaoui A, Bradesi S, Fioramonti J, Theodorou V, Bueno L. Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: role of myosin light chain kinase. Pain. 2005;113:141-147.
-
- Aggarwal A, Cutts TF, Abell TL, Cardoso S, Familoni B, Bremer J, et al. Predominant symptoms in irritable bowel syndrome correlate with specific autonomic nervous system abnormalities. Gastroenterology. 1994;106:945-950.
-
- Akiho H, Deng Y, Blennerhassett P, Kanbayashi H, Collins SM. Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction. Gastroenterology. 2005;129:131-141.
-
- Akopian AN, Souslova V, England S, Okuse K, Ogata N, Ure J, et al. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci. 1999;2:541-548.
-
- Al-Chaer ED, Feng Y, Willis WD. Comparative study of viscerosomatic input onto postsynaptic dorsal column and spinothalamic tract neurons in the primate. J Neurophysiol. 1999;82:1876-1882.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical