Massage therapy versus simple touch to improve pain and mood in patients with advanced cancer: a randomized trial
- PMID: 18794556
- PMCID: PMC2631433
- DOI: 10.7326/0003-4819-149-6-200809160-00003
Massage therapy versus simple touch to improve pain and mood in patients with advanced cancer: a randomized trial
Abstract
Background: Small studies of variable quality suggest that massage therapy may relieve pain and other symptoms.
Objective: To evaluate the efficacy of massage for decreasing pain and symptom distress and improving quality of life among persons with advanced cancer.
Design: Multisite, randomized clinical trial.
Setting: Population-based Palliative Care Research Network.
Patients: 380 adults with advanced cancer who were experiencing moderate-to-severe pain; 90% were enrolled in hospice.
Intervention: Six 30-minute massage or simple-touch sessions over 2 weeks.
Measurements: Primary outcomes were immediate (Memorial Pain Assessment Card, 0- to 10-point scale) and sustained (Brief Pain Inventory [BPI], 0- to 10-point scale) change in pain. Secondary outcomes were immediate change in mood (Memorial Pain Assessment Card) and 60-second heart and respiratory rates and sustained change in quality of life (McGill Quality of Life Questionnaire, 0- to 10-point scale), symptom distress (Memorial Symptom Assessment Scale, 0- to 4-point scale), and analgesic medication use (parenteral morphine equivalents [mg/d]). Immediate outcomes were obtained just before and after each treatment session. Sustained outcomes were obtained at baseline and weekly for 3 weeks.
Results: 298 persons were included in the immediate outcome analysis and 348 in the sustained outcome analysis. A total of 82 persons did not receive any allocated study treatments (37 massage patients, 45 control participants). Both groups demonstrated immediate improvement in pain (massage, -1.87 points [95% CI, -2.07 to -1.67 points]; control, -0.97 point [CI, -1.18 to -0.76 points]) and mood (massage, 1.58 points [CI, 1.40 to 1.76 points]; control, 0.97 point [CI, 0.78 to 1.16 points]). Massage was superior for both immediate pain and mood (mean difference, 0.90 and 0.61 points, respectively; P < 0.001). No between-group mean differences occurred over time in sustained pain (BPI mean pain, 0.07 point [CI, -0.23 to 0.37 points]; BPI worst pain, -0.14 point [CI, -0.59 to 0.31 points]), quality of life (McGill Quality of Life Questionnaire overall, 0.08 point [CI, -0.37 to 0.53 points]), symptom distress (Memorial Symptom Assessment Scale global distress index, -0.002 point [CI, -0.12 to 0.12 points]), or analgesic medication use (parenteral morphine equivalents, -0.10 mg/d [CI, -0.25 to 0.05 mg/d]).
Limitations: The immediate outcome measures were obtained by unblinded study therapists, possibly leading to reporting bias and the overestimation of a beneficial effect. The generalizability to all patients with advanced cancer is uncertain. The differential beneficial effect of massage therapy over simple touch is not conclusive without a usual care control group.
Conclusion: Massage may have immediately beneficial effects on pain and mood among patients with advanced cancer. Given the lack of sustained effects and the observed improvements in both study groups, the potential benefits of attention and simple touch should also be considered in this patient population.
Figures
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Summary for patients in
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Massage therapy to improve pain and mood in patients with advanced cancer.Ann Intern Med. 2008 Sep 16;149(6):I38. doi: 10.7326/0003-4819-149-6-200809160-00001. Ann Intern Med. 2008. PMID: 18794554 No abstract available.
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References
-
- Singer PA, Martin DK, Kelner M. Quality end-of-life care: patients’ perspectives. JAMA. 1999;281:163–68. - PubMed
-
- Kutner JS, Kassner CT, Nowels DE. Symptom Burden at the End of Life: Hospice Providers’ Perceptions. J Pain Symptom Manage. 2001;21:473–80. - PubMed
-
- Bruera E. Research into symptoms other than pain. In: Doyle D, Hanks GW, MacDonald N, editors. Oxford Textbook of Palliative Medicine. 2. New York: Oxford University Press; 1998.
-
- Kutner JS, Bryant LL, Beaty BL, Fairclough DL. Time Course and Characteristics of Symptom Distress and Quality of Life at the End of Life. J Pain Sympt Manage. 2007;34:227–36. - PubMed
-
- National Institutes of Health. National Institutes of Health State-of-the-Science Conference Statement: Improving End-of-Life Care. [October 15, 2005]. http://consensus.nih.gov/
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