Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults
- PMID: 18708688
- DOI: 10.1123/ijsnem.18.4.389
Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults
Abstract
The purpose of this study was to compare changes in muscle insulin-like growth factor-I (IGF-I) content resulting from resistance-exercise training (RET) and creatine supplementation (CR). Male (n=24) and female (n=18) participants with minimal resistance-exercise-training experience (=1 year) who were participating in at least 30 min of structured physical activity (i.e., walking, jogging, cycling) 3-5 x/wk volunteered for the study. Participants were randomly assigned in blocks (gender) to supplement with creatine (CR: 0.25 g/kg lean-tissue mass for 7 days; 0.06 g/kg lean-tissue mass for 49 days; n=22, 12 males, 10 female) or isocaloric placebo (PL: n=20, 12 male, 8 female) and engage in a whole-body RET program for 8 wk. Eighteen participants were classified as vegetarian (lacto-ovo or vegan; CR: 5 male, 5 female; PL: 3 male, 5 female). Muscle biopsies (vastus lateralis) were taken before and after the intervention and analyzed for IGF-I using standard immunohistochemical procedures. Stained muscle cross-sections were examined microscopically and IGF-I content quantified using image-analysis software. Results showed that RET increased intramuscular IGF-I content by 67%, with greater accumulation from CR (+78%) than PL (+54%; p=.06). There were no differences in IGF-I between vegetarians and nonvegetarians. These findings indicate that creatine supplementation during resistance-exercise training increases intramuscular IGF-I concentration in healthy men and women, independent of habitual dietary routine.
Similar articles
-
Elevation of creatine in red blood cells in vegetarians and nonvegetarians after creatine supplementation.Can J Appl Physiol. 2004 Dec;29(6):704-13. doi: 10.1139/h04-045. Can J Appl Physiol. 2004. PMID: 15630144 Clinical Trial.
-
Effect of creatine and weight training on muscle creatine and performance in vegetarians.Med Sci Sports Exerc. 2003 Nov;35(11):1946-55. doi: 10.1249/01.MSS.0000093614.17517.79. Med Sci Sports Exerc. 2003. PMID: 14600563 Clinical Trial.
-
Effects of creatine supplementation and exercise training on fitness in men 55-75 yr old.J Appl Physiol (1985). 2003 Aug;95(2):818-28. doi: 10.1152/japplphysiol.00891.2002. Epub 2003 Mar 28. J Appl Physiol (1985). 2003. PMID: 12665537 Clinical Trial.
-
Nutritional supplementation and resistance exercise: what is the evidence for enhanced skeletal muscle hypertrophy?Can J Appl Physiol. 2000 Dec;25(6):524-35. doi: 10.1139/h00-034. Can J Appl Physiol. 2000. PMID: 11098159 Review.
-
Creatine supplementation. Its role in human performance.Clin Sports Med. 1999 Jul;18(3):651-66, ix. doi: 10.1016/s0278-5919(05)70174-5. Clin Sports Med. 1999. PMID: 10410847 Review.
Cited by
-
Supplementation for Performance and Health in Patients with Phenylketonuria: An Exercise-Based Approach to Improving Dietary Adherence.Nutrients. 2024 Feb 25;16(5):639. doi: 10.3390/nu16050639. Nutrients. 2024. PMID: 38474766 Free PMC article. Review.
-
Interaction effects of glycine equivalent and standardized ileal digestible threonine in low protein diets for broiler grower chickens.Anim Biosci. 2024 Jun;37(6):1053-1064. doi: 10.5713/ab.23.0307. Epub 2024 Feb 22. Anim Biosci. 2024. PMID: 38419547 Free PMC article.
-
Creatine as a Therapeutic Target in Alzheimer's Disease.Curr Dev Nutr. 2023 Sep 29;7(11):102011. doi: 10.1016/j.cdnut.2023.102011. eCollection 2023 Nov. Curr Dev Nutr. 2023. PMID: 37881206 Free PMC article. Review.
-
Implementation and Core Components of a Multimodal Program including Exercise and Nutrition in Prevention and Treatment of Frailty in Community-Dwelling Older Adults: A Narrative Review.Nutrients. 2023 Sep 22;15(19):4100. doi: 10.3390/nu15194100. Nutrients. 2023. PMID: 37836384 Free PMC article. Review.
-
Effects of Four Weeks of Beta-Alanine Supplementation Combined with One Week of Creatine Loading on Physical and Cognitive Performance in Military Personnel.Int J Environ Res Public Health. 2022 Jun 29;19(13):7992. doi: 10.3390/ijerph19137992. Int J Environ Res Public Health. 2022. PMID: 35805647 Free PMC article. Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical