Neuron-astrocyte signaling in the development and plasticity of neural circuits
- PMID: 18635944
- DOI: 10.1159/000123038
Neuron-astrocyte signaling in the development and plasticity of neural circuits
Abstract
Emerging evidence indicates that signaling between perisynaptic astrocytes and neurons at the tripartite synapse plays an important role during the critical period when neural circuits are formed and refined. Cross-talk between astrocytes and neurons during development mediates synaptogenesis, synapse elimination and structural plasticity through a variety of secreted and contact-dependent signals. Recent live imaging studies reveal a dynamic and cooperative interplay between astrocytes and neurons at synapses that is guided by a variety of molecular cues. A unifying theme from these recent findings is that astrocytes can promote the development and plasticity of synaptic circuits. Insight into the molecular mechanisms by which astrocytes regulate the wiring of the brain during development could lead to new therapeutic strategies to promote repair and rewiring of neural circuits in the mature brain following CNS injury and neurodegenerative disease.
Copyright 2008 S. Karger AG, Basel.
Similar articles
-
Neuron-astrocyte communication and synaptic plasticity.Curr Opin Neurobiol. 2010 Aug;20(4):466-73. doi: 10.1016/j.conb.2010.04.008. Epub 2010 May 12. Curr Opin Neurobiol. 2010. PMID: 20471242
-
Signaling between glia and neurons: focus on synaptic plasticity.Curr Opin Neurobiol. 2005 Oct;15(5):542-8. doi: 10.1016/j.conb.2005.08.006. Curr Opin Neurobiol. 2005. PMID: 16144764 Review.
-
Morphological plasticity of rodent astroglia.J Neurochem. 2013 Feb;124(3):263-75. doi: 10.1111/jnc.12087. Epub 2012 Dec 26. J Neurochem. 2013. PMID: 23278277 Review.
-
Experience-dependent structural synaptic plasticity in the mammalian brain.Nat Rev Neurosci. 2009 Sep;10(9):647-58. doi: 10.1038/nrn2699. Nat Rev Neurosci. 2009. PMID: 19693029 Review.
-
Astrocytes and synaptic plasticity.Neuroscientist. 2010 Feb;16(1):40-50. doi: 10.1177/1073858409339215. Neuroscientist. 2010. PMID: 20236948 Review.
Cited by
-
Role and limitation of cell therapy in treating neurological diseases.Ibrain. 2024 Mar 12;10(1):93-105. doi: 10.1002/ibra.12152. eCollection 2024 Spring. Ibrain. 2024. PMID: 38682022 Free PMC article. Review.
-
Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells.Brain Sci. 2024 Mar 15;14(3):284. doi: 10.3390/brainsci14030284. Brain Sci. 2024. PMID: 38539672 Free PMC article. Review.
-
The Janus face of antipsychotics in glial cells: Focus on glioprotection.Exp Biol Med (Maywood). 2023 Nov;248(22):2120-2130. doi: 10.1177/15353702231222027. Epub 2024 Jan 17. Exp Biol Med (Maywood). 2023. PMID: 38230521 Free PMC article. Review.
-
Publicly available ex vivo transcriptomics datasets to explore CNS physiology and neurodegeneration: state of the art and perspectives.Front Neurosci. 2023 Aug 23;17:1211079. doi: 10.3389/fnins.2023.1211079. eCollection 2023. Front Neurosci. 2023. PMID: 37680966 Free PMC article. Review.
-
Aquaporin-4 Deficiency is Associated with Cognitive Impairment and Alterations in astrocyte-neuron Lactate Shuttle.Mol Neurobiol. 2023 Nov;60(11):6212-6226. doi: 10.1007/s12035-023-03475-9. Epub 2023 Jul 12. Mol Neurobiol. 2023. PMID: 37436602
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources